Fatty acids composition of Chylomicron remnants like particles influences their uptake and induction of lipid accumulation in macrophages.

The influence of the fatty acid composition of chylomicron remnant-like particles (CRLPs) on their uptake and induction of lipid accumulation in macrophages was studied. CRLPs containing triacylglycerol enriched in saturated, monounsaturated, n−6 or n−3 polyunsaturated fatty acids derived from palm, olive, corn or fish oil, respectively, and macrophages derived from the human monocyte cell line THP-1 were used. Lipid accumulation (triacylglycerol and cholesterol) in the cells was measured after incubation with CRLPs for 5, 24 and 48 h, and uptake over 24 h was determined using CRLPs radiolabelled with [3H]triolein. Total lipid accumulation in the macrophages was significantly greater with palm CRLPs than with the other three types of particle. This was mainly due to increased triacylglycerol concentrations, whereas changes in cholesterol concentrations did not reach significance. There were no significant differences in lipid accumulation after incubation with olive, corn or fish CRLPs. Palm and olive CRLPs were taken up by the cells at a similar rate, which was considerably faster than that observed with corn and fish CRLPs. These findings demonstrate that CRLPs enriched in saturated or monounsaturated fatty acids are taken up more rapidly by macrophages than those enriched in n−6 or n−3 polunsaturated fatty acids, and that the faster uptake rate results in greater lipid accumulation in the case of saturated fatty acid-rich particles, but not monounsaturated fatty acid-rich particles. Thus, dietary saturated fatty acids carried in chylomicron remnants may enhance their propensity to induce macrophage foam cell formation.

The impacts of telecommuting in Dublin

Telecommuting has been perceived as an effective means of reducing commuter related trips, travel time and emissions. Previously, the lack of access to broadband Internet connection and teleconferencing software from home has acted as a barrier to telecommuting regularly or at all. However, with advances in information and communication technology in recent years telecommuting is becoming a viable option for employers and employees to undertake. This paper examines the current trends of full day and part day telecommuting in the Greater Dublin Area (GDA), and attempts to ascertain the most influential drivers and constraints related to telecommuting. The research presented estimates of the environmental benefits from individuals that telecommute. Finally, this paper seeks to determine the magnitude of carbon emissions savings from individuals adopting telecommuting and provides a social cost of carbon saving value. The survey results presented suggest that approximately 44% of the population of the GDA telecommute at least once a month. The findings also indicate that needing contact with colleagues is the most influential constraint to telecommuting, while greater flexibility and avoiding travelling in peak periods are the most important drivers in the propensity to telecommute. Finally, this study shows that there are substantial carbon reductions and social cost of carbon savings. Thus illustrating how telecommuting can be a viable and sustainable policy in the GDA or in other similar sized regions.