Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention

Protein tyrosine phosphatases have been the focus of considerable research efforts aimed at developing novel therapeutics; however, these targets are often characterized as being ‘undruggable’ due to the challenge of achieving selectivity, potency and cell permeability. More recently, there has been renewed interest in developing inhibitors of the tyrosine phosphatase SHP2 (PTPN11) in the light of its broad role in cancer, specifically juvenile myelomonocytic leukemia, and recent studies that implicate SHP2 as a key factor in breast cancer progression. Recent significant advances in the field of SHP2 inhibitor development raise the question: are we on the verge of a new era of protein tyrosine phosphatase-directed therapeutics? This article critically appraises recent developments, assesses ongoing challenges and presents a perspective on possible future directions.

Compulsive Buying: Literature Review and Suggestions for Future Research

Compulsive buying is a serious, but under researched, aspect of consumer buying behaviour. Setting the review in a historical context, the review begins by addressing the earliest works on the subject and seminal papers by leading researchers in the field of compulsive buying. The review addresses the fact that Emil Kraepelin first identified compulsive buying in his 1915 textbook, before the subject faced an almost complete hiatus in terms of research until the late 1980s where the issue was addressed by a number of leading consumer behaviour researchers. The review will then proceed chronologically and thematically, addressing each issue and theme that has emerged from the literature. Previous directions of the research will be discussed, whilst guiding readers towards the current landscape of the research, and a suggestion of the next logical direction of the research.