16 resultados para cytochrome c oxidase subunit I

em WestminsterResearch - UK


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I and Q Channel phase and gain mismatches are of great concern in communications receiver design. In this paper we carry out a detailed performance analysis of the Blind-Source Seperation (BSS) based imbalance compensation structure. The results indicate that the BSS structure can offer adequate performance for most communication systems. Since the compensation is carried out before any modulation specific processing, the proposed compensation method works with all standard modulation formats.

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I and Q Channel phase and gain misniatches are of great concern in communications receiver design. In this paper we analyse the effects of I and Q channel mismatches and propose a low-complexity blind adaptive algorithm to minimize this problem. The proposed solution consists of two, 2-tap adaptive filters, arranged in Adaptive Noise Canceller (ANC) set-up, with the output of one cross-fed to the input of the other. The system works as a de-correlator eliminating I and Q mismatch errors.

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This paper presents a new design approach for a rail-to-rail bulk-driven input stage using a standard single-well (n-well in this paper) CMOS technology. This input stage can provide nearly constant transconductance and constant slew rate over the entire input common-mode voltage, operating with a wide supply voltage ranging from sub 1-volt (V/sub T0/+ 3V/sub DSsat/) to the maximum allowed for the CMOS process, as well as preventing latch-up.

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Polyphase IIR structures have recently proven themselves very attractive for very high performance filters that can be designed using very few coefficients. This, combined with their low sensitivity to coefficient quantization in comparison to standard FIR and IIR structures, makes them very applicable for very fast filtering when implemented in fixed-point arithmetic. However, although the mathematical description is very simple, there exist a number of ways to implement such filters. In this paper, we take four of these different implementation structures, analyze the rounding noise originating from the limited arithmetic wordlength of the mathematical operators, and check the internal data growth within the structure. These analyses need to be done to ensure that the performance of the implementation matches the performance of the theoretical design. The theoretical approach that we present has been proven by the results of the fixed-point simulation done in Simulink and verified by an equivalent bit-true implementation in VHDL.

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This paper describes in detail the design of a CMOS custom fast Fourier transform (FFT) processor for computing a 256-point complex FFT. The FFT is well-suited for real-time spectrum analysis in instrumentation and measurement applications. The FFT butterfly processor reported here consists of one parallel-parallel multiplier and two adders. It is capable of computing one butterfly computation every 100 ns thus it can compute a 256-point complex FFT in 102.4 μs excluding data input and output processes.

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This paper describes in detail the design of a custom CMOS Fast Fourier Transform (FFT) processor for computing 256-point complex FFT. The FFT is well suited for real-time spectrum analysis in instrumentation and measurement applications. The FFT butterfly processor consists of one parallel-parallel multiplier and two adders. It is capable of computing one butterfly computation every 100 ns thus it can compute 256-complex point FFT in 25.6 μs excluding data input and output processes.

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A simple but effective technique to improve the performance of the Max-Log-MAP algorithm is to scale the extrinsic information exchanged between two MAP decoders. A comprehensive analysis of the selection of the scaling factors according to channel conditions and decoding iterations is presented in this paper. Choosing a constant scaling factor for all SNRs and iterations is compared with the best scaling factor selection for changing channel conditions and decoding iterations. It is observed that a constant scaling factor for all channel conditions and decoding iterations is the best solution and provides a 0.2-0.4 dB gain over the standard Max- Log-MAP algorithm. Therefore, a constant scaling factor should be chosen for the best compromise.

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The iterative nature of turbo-decoding algorithms increases their complexity compare to conventional FEC decoding algorithms. Two iterative decoding algorithms, Soft-Output-Viterbi Algorithm (SOVA) and Maximum A posteriori Probability (MAP) Algorithm require complex decoding operations over several iteration cycles. So, for real-time implementation of turbo codes, reducing the decoder complexity while preserving bit-error-rate (BER) performance is an important design consideration. In this chapter, a modification to the Max-Log-MAP algorithm is presented. This modification is to scale the extrinsic information exchange between the constituent decoders. The remainder of this chapter is organized as follows: An overview of the turbo encoding and decoding processes, the MAP algorithm and its simplified versions the Log-MAP and Max-Log-MAP algorithms are presented in section 1. The extrinsic information scaling is introduced, simulation results are presented, and the performance of different methods to choose the best scaling factor is discussed in Section 2. Section 3 discusses trends and applications of turbo coding from the perspective of wireless applications.

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The UMTS turbo encoder is composed of parallel concatenation of two Recursive Systematic Convolutional (RSC) encoders which start and end at a known state. This trellis termination directly affects the performance of turbo codes. This paper presents performance analysis of multi-point trellis termination of turbo codes which is to terminate RSC encoders at more than one point of the current frame while keeping the interleaver length the same. For long interleaver lengths, this approach provides dividing a data frame into sub-frames which can be treated as independent blocks. A novel decoding architecture using multi-point trellis termination and collision-free interleavers is presented. Collision-free interleavers are used to solve memory collision problems encountered by parallel decoding of turbo codes. The proposed parallel decoding architecture reduces the decoding delay caused by the iterative nature and forward-backward metric computations of turbo decoding algorithms. Our simulations verified that this turbo encoding and decoding scheme shows Bit Error Rate (BER) performance very close to that of the UMTS turbo coding while providing almost %50 time saving for the 2-point termination and %80 time saving for the 5-point termination.

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Turbo codes experience a significant decoding delay because of the iterative nature of the decoding algorithms, the high number of metric computations and the complexity added by the (de)interleaver. The extrinsic information is exchanged sequentially between two Soft-Input Soft-Output (SISO) decoders. Instead of this sequential process, a received frame can be divided into smaller windows to be processed in parallel. In this paper, a novel parallel processing methodology is proposed based on the previous parallel decoding techniques. A novel Contention-Free (CF) interleaver is proposed as part of the decoding architecture which allows using extrinsic Log-Likelihood Ratios (LLRs) immediately as a-priori LLRs to start the second half of the iterative turbo decoding. The simulation case studies performed in this paper show that our parallel decoding method can provide %80 time saving compared to the standard decoding and %30 time saving compared to the previous parallel decoding methods at the expense of 0.3 dB Bit Error Rate (BER) performance degradation.

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Alcohol binge drinking, especially in teenagers and young adults is a major public health issue in the UK, with the number of alcohol related liver disorders steadily increasing. Understanding the mechanisms behind liver disease arising from binge-drinking and finding ways to prevent such damage are currently important areas of research. In the present investigation the effect of acute ethanol administration on hepatic oxidative damage and apoptosis was examined using both an in vivo and in vitro approach; the effect of micronutrient supplementation prior and during ethanol exposure was also studied. The following studies were performed: (1) ethanol administration (75 mmol/kg body weight) and cyanamide pre-treatment followed by ethanol to study elevated acetaldehyde levels with liver tissue analysed 2.5, 6 and 24 hours post-alcohol; (2). Using juvenile animals, 2% betaine supplementation followed by acute ethanol with tissue analysed 24 hrs post ethanol; and (3). Micronutrient supplementation during concomitant ethanol exposure to hepG2 cells. It was found that a single dose of alcohol caused oxidative damage to the liver of rats at 2.5 hr post-alcohol as evidenced by decreased glutathione levels and increased malondialdehyde levels in both the cytosol and mitochondria. Liver function was also depressed but there were no findings of apoptosis as cytochrome c levels and caspase 3 activity was unchanged. At 6 hours, the effect of ethanol was reduced suggesting some degree of recovery, however, by 24 hours, increased mitochondrial oxidative stress was apparent. The effect of elevated acetaldehyde on hepatic damage was particularly evident at 24 hours, with some oxidative changes at earlier time points. At 24 hours, acetaldehyde caused a profound drop in glutathione levels in the cytosol and hepatic function was still deteriorating. Studies examining ethanol exposure to juvenile livers showed that glutathione levels were increased, suggesting an overtly protective response not seen in with older animals. It also showed that despite cytochrome c release into the cytosol, caspase-3 levels were not increased. This suggests that ATP depletion is preventing apoptosis initiation. Betaine supplementation prevented almost all of the alcohol-mediated changes, suggesting that the main mechanism behind alcohol-mediated liver damage is oxidative stress. Results using the hepG2 cell line model showed that micronutrients involved in glutathione synthesis can protect against hepatocyte damage caused by alcohol metabolism, with reduced reactive oxygen species and increased/maintained glutathione levels. In summary, these results demonstrate that both acute alcohol and acetaldehyde can have damaging effects to the liver, but that dietary intervention may be able to protect against ethanol induced oxidative stress.

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This paper describes a novel idea to identify the total number of red blood cells (RBCs) as well as their location in a Giemsa stained thin blood film image. This work is being undertaken as a part of developing an automated malaria parasite detection system by scanning a photograph of thin blood film in order to evaluate the parasitemia of the blood. Not only will this method eliminates the segmentation procedures that are normally used to segment the cells in the microscopic image, but also avoids any image pre-processing to deal with non uniform illumination prior to cell detection. The method utilizes basic knowledge on cell structure and brightness of the components due to Giemsa staining of the sample and detects and locates the RBCs in the image.

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This paper demonstrates nonlinear phase filtering effects on GNSS receiver accuracy. Using a nonlinear phase filter in a GNSS receiver can change the pseudorange estimation up to 250 metres which introduces an error in the overall positioning calculation. Paper shows the study of the nonlinear phase filtering effects on the pseudorange estimation and demonstrates how it can be compensated with minimal hardware usage.

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This paper compares a carrier tracking scenario when a received Global Positioning System (GPS) signal has low Doppler frequency. It is shown that if the Numerically Controlled Oscillator (NCO) is quantized to 1 bit, the carrier tracking loop is unable to keep track of the incoming signal which leaves the tracking loop oscillating between the upper and lower bounds of the tracking loop bandwidth. One way of overcoming this problem is presented and compared with another existing solution, found in the literature, providing comparative results from the use of real-recorded off the air GPS L1 signals. Results show that the proposed method performs better tracking performance compared with the existing solution which it requires much less hardware complexity.