Inkjet-Printed Filtennas with Triple Bandnotch

This paper presents the layout and results of a compact inkjet-printed filtenna operating at the S-band, ISM and UWB frequencies. The filtenna has a wide passband and, alongside, rejects WiMAX 3.5 GHz, WLAN 5.8 GHz and ITU service 8.2 GHz bands. The filtenna is simulated, printed using silver nanoparticle ink on flexible Kapton substrate and measured. Obtained simulation and measurement results agree well with each other. Measured return loss of the filtenna is more than 10 dB for 1.6–10.85 GHz and triple bandnotch, measuring at an average of 1.87 dB, are present at the unwanted bands. Radiation patterns, as well as the gain and efficiency of the filtenna have also been presented; with the average values being 3.4 dBi and 90 % respectively for the passband and averaging at −1.0 dBi and 22 % respectively for the three rejected bands.

Identification of Streptococcus gallolyticus subsp. macedonicus as the etiological agent in a case of culture-negative multivalve infective endocarditis by 16S rDNA PCR analysis of resected valvular tissue

Today, PCR using broad-range primers is being used increasingly to detect pathogens from resected heart valves. Herein is described the first case of multivalve infective endocarditis where 16S rDNA PCR was used to detect a single pathogen from two affected valves in a 61-year-old man. Triple heart valve replacement was required despite six weeks of appropriate antimicrobial therapy. The organism was confirmed as Streptococcus gallolyticus subsp. macedonicus, a member of the 'S. equinus/S. bovis' complex. To date, only one report has been made of human infection due to this organism. This may be due to the limited resolution of the routine diagnostic methods used and/or as a consequence of the complex nomenclature associated with this group of organisms.

MASH structures for bandpass sigma-delta modulators

The paper presents simulation results from investigating the behaviour of multistage (MASH) oversampled bandpass sigma-delta (Σ-Δ) modulators for use in analogue to digital converters for high frequency narrowband applications such as the signals out of the intermediate frequency (IF) section of a superheterodyne radio receiver. The bandpass configurations under consideration have in their loop filter a cascade of second-order resonator structures in order to achieve acceptable noise shaping. The quantisation noise in each stage is suppressed by feeding the error of each section into the input of the following stages. It is demonstrated that the triple effective-first-order bandpass MASH structure has significantly better performance compared with the effective-second-order effective-first-order bandpass MASH structure.

Telaprevir or boceprevir based therapy for chronic hepatitis C infection: Development of resistance-associated variants in treatment failure

The use of triple-therapy, pegylated-interferon, ribavirin and either of the first generation hepatitis C virus (HCV) protease inhibitors telaprevir or boceprevir, is the new standard of care for treating genotype 1 chronic HCV. Clinical trials have shown response rates of around 70–80%, but there is limited data from the use of this combination outside this setting. Through an expanded access programme, we treated 59 patients, treatment naïve and experienced, with triple therapy. Baseline factors predicting treatment response or failure during triple therapy phase were identified in 58 patients. Thirty seven (63.8%) of 58 patients had undetectable HCV RNA 12 weeks after the end of treatment. Genotype 1a (p = 0.053), null-response to previous treatment (p = 0.034), the rate of viral load decline after 12 weeks of previous interferon-based treatment (p = 0.033) were all associated with triple-therapy failure. The most common cause of on-treatment failure for telaprevir-based regimens was the development of resistance-associated variants (RAVs) at amino acids 36 and/or 155 of HCV protease (p = 0.027) whereas in boceprevir-based regimens mutations at amino acid 54 were significant (p = 0.015). SVR12 rates approaching 64% were achieved using triple therapy outside the clinical trial setting, in a patient cohort that included cirrhotics.

Alienation and Digital Labour – a Depth-Hermeneutic Inquiry into Online Commodification and the Unconscious

At the core of this paper is a psychosocial inquiry into the Marxist concept of alienation and its applications to the field of digital labour. Following a brief review of different theoretical works on alienation, it looks into its recent conceptualisations and applications to the study of online social networking sites. Finally, the authors offer suggestions on how to extend and render more complex these recent approaches through in-depth analyses of Facebook posts that exemplify how alienation is experienced, articulated, and expressed online. For this perspective, the article draws on Rahel Jaeggi’s (2005) reassessment of alienation, as well as the depth-hermeneutic method of “scenic understanding” developed by Alfred Lorenzer (e.g. 1970; 1986).