3 resultados para Intervention development

em WestminsterResearch - UK


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Protein tyrosine phosphatases have been the focus of considerable research efforts aimed at developing novel therapeutics; however, these targets are often characterized as being ‘undruggable’ due to the challenge of achieving selectivity, potency and cell permeability. More recently, there has been renewed interest in developing inhibitors of the tyrosine phosphatase SHP2 (PTPN11) in the light of its broad role in cancer, specifically juvenile myelomonocytic leukemia, and recent studies that implicate SHP2 as a key factor in breast cancer progression. Recent significant advances in the field of SHP2 inhibitor development raise the question: are we on the verge of a new era of protein tyrosine phosphatase-directed therapeutics? This article critically appraises recent developments, assesses ongoing challenges and presents a perspective on possible future directions.

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The paper explores the issue of temporary projects on vacant land focusing on London in the 2007-2012 downturn. Using a case study approach, a link has been identified between the success of temporary projects and a longer-term vision, as well as a move toward better integration between temporary occupants and developer/land-owner. Within this paradox the whole idea of temporariness is put under question, as is the traditional mainstream depiction of bottom-up in opposition to top-down action. These trends are contextualised within the dynamics of recession that has triggered new types of creative conversations between parties traditionally considered in opposition and may contribute to reframing urban development as an incremental, organic and collaborative process.

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We are witnessing nothing less than a revolution in international policy-thinking, with a shift from imagining that international policy-makers can solve development/ security problems through the export or transfer of policy practices or their imposition through conditionality, to understanding that problems should be grasped as emergent consequences of complex social processes which need to be worked with rather than against. This paper, prepared for the 2014 CEPA conference, focuses therefore less on the politicisation and securitisation of questions of conflict and poverty and more on the depoliticisation of questions of conflict and poverty, especially through frameworks of resilience.