Fatty acids composition of Chylomicron remnants like particles influences their uptake and induction of lipid accumulation in macrophages.

The influence of the fatty acid composition of chylomicron remnant-like particles (CRLPs) on their uptake and induction of lipid accumulation in macrophages was studied. CRLPs containing triacylglycerol enriched in saturated, monounsaturated, n−6 or n−3 polyunsaturated fatty acids derived from palm, olive, corn or fish oil, respectively, and macrophages derived from the human monocyte cell line THP-1 were used. Lipid accumulation (triacylglycerol and cholesterol) in the cells was measured after incubation with CRLPs for 5, 24 and 48 h, and uptake over 24 h was determined using CRLPs radiolabelled with [3H]triolein. Total lipid accumulation in the macrophages was significantly greater with palm CRLPs than with the other three types of particle. This was mainly due to increased triacylglycerol concentrations, whereas changes in cholesterol concentrations did not reach significance. There were no significant differences in lipid accumulation after incubation with olive, corn or fish CRLPs. Palm and olive CRLPs were taken up by the cells at a similar rate, which was considerably faster than that observed with corn and fish CRLPs. These findings demonstrate that CRLPs enriched in saturated or monounsaturated fatty acids are taken up more rapidly by macrophages than those enriched in n−6 or n−3 polunsaturated fatty acids, and that the faster uptake rate results in greater lipid accumulation in the case of saturated fatty acid-rich particles, but not monounsaturated fatty acid-rich particles. Thus, dietary saturated fatty acids carried in chylomicron remnants may enhance their propensity to induce macrophage foam cell formation.

Reconfigurable UWB Filtennas with Dual Bandnotch for Unwanted Bands using Graphene based Switches

Presented are the design and results of a reconfigurable UWB filtenna with sharp dual bandnotch at WiMAX 3.5 GHz and WLAN 5.8 GHz bands. The filtenna is formed by placing three loop resonators in an UWB antenna. The resonators are fitted with Graphene based switches which introduce reconfigurability. The filtenna was simulated electromagnetically and with Graphene based switches in switches OFF and switches ON states. Presented results show a passband from 2.81–12.27 GHz in OFF state and ON state results in sharp dual bandnotch within the passband at 3.45 and 5.95 GHz at a return loss of 2–2.5 dB. The gain and efficiency in both states has also been given and is reduced in ON state at the dual bandnotch. The radiation patterns in E- and H-planes are stable.

Inkjet-Printed Filtennas with Triple Bandnotch

This paper presents the layout and results of a compact inkjet-printed filtenna operating at the S-band, ISM and UWB frequencies. The filtenna has a wide passband and, alongside, rejects WiMAX 3.5 GHz, WLAN 5.8 GHz and ITU service 8.2 GHz bands. The filtenna is simulated, printed using silver nanoparticle ink on flexible Kapton substrate and measured. Obtained simulation and measurement results agree well with each other. Measured return loss of the filtenna is more than 10 dB for 1.6–10.85 GHz and triple bandnotch, measuring at an average of 1.87 dB, are present at the unwanted bands. Radiation patterns, as well as the gain and efficiency of the filtenna have also been presented; with the average values being 3.4 dBi and 90 % respectively for the passband and averaging at −1.0 dBi and 22 % respectively for the three rejected bands.

Stepped-bend Substrate Integrated Waveguide to Rectangular Waveguide Transition

A new wideband transition between substrate integrated waveguide (SIW) and rectangular waveguide (RWG) that resembles a right angle waveguide E-bend at Ku/K band is presented. The transition has removable but stable mounting, requires only PCB fabrication and has adaptable quality and bandwidth characteristics depending on the number of substrate layers used.