Loss of Outer Retinal Neurons and Circuitry Alterations in the DBA/2J Mouse

Purpose. The DBA/2J mouse line develops essential iris atrophy, pigment dispersion, and glaucomatous age-related changes, including an increase of IOP, optic nerve atrophy, and retinal ganglion cell (RGC) death. The aim of this study was to evaluate possible morphological changes in the outer retina of the DBA/2J mouse concomitant with disease progression and aging, based on the reduction of both the a- and b-waves and photopic flicker ERGs in this mouse line. Methods. Vertically sectioned DBA/2J mice retinas were evaluated at 3, 8, and 16 months of age using photoreceptor, horizontal, and bipolar cell markers. Sixteen-month-old C57BL/6 mice retinas were used as controls. Results. The DBA/2J mice had outer retinal degeneration at all ages, with the most severe degeneration in the oldest retinas. At 3 months of age, the number of photoreceptor cells and the thickness of the OPL were reduced. In addition, there was a loss of horizontal and ON-bipolar cell processes. At 8 months of age, RGC degeneration occurred in patches, and in the outer retina overlying these patches, cone morphology was impaired with a reduction in size as well as loss of outer segments and growth of horizontal and bipolar cell processes into the outer nuclear layer. At 16 months of age, connectivity between photoreceptors and horizontal and bipolar cell processes overlying these patches was lost. Conclusions. Retinal degeneration in DBA/2J mice includes photoreceptor death, loss of bipolar and horizontal cell processes, and loss of synaptic contacts in an aging-dependent manner.

SERS Active Surface in Two Steps, Patterning and Metallization

Robust and reproducible metallized nano/microstructured surfaces of polymeric surfaces have been successfully prepared by direct laser interference patterning (DLIP) of commercial polymeric films followed by sputtering of metallic thin films. The SERS spectra for 2-thioaniline adsorbed on a structured polycarbonate surfaces covered with a gold or platinum film showed a ca. three order of magnitude enhancement over a flat surface with the same metal film. The method here reported is suitable for mass production of substrates for SERS since large areas (several cm2) can be structured in ca. 1–5 s.

La participación ciudadana como instrumento para la planificación e investigación social en turismo

Este trabajo profundiza en el potencial de la participación ciudadana como herramienta para el diagnóstico y planificación turística, así como fuente de conocimiento para el científico social. Se expone la metodología y principales resultados de un proceso participativo en un municipio turístico-residencial dirigido al diseño colaborado de propuestas de actuación a escala local. Este proceso ofreció un espacio para la reflexión ciudadana sobre las implicaciones del modelo turístico-urbanístico y sus posibilidades de futuro, y proporcionó un mecanismo para el acercamiento de las necesidades y opiniones ciudadanas a los procesos de planificación y toma de decisiones municipales. Además, a partir de un análisis de contenido de los documentos elaborados por los participantes, se demuestra la utilidad de la participación ciudadana como recurso de alta riqueza informativa para la investigación social en el ámbito del turismo.

Detailing for a research centre in Antarctica: An experiment to force students to be creative instead of copying standard solutions

In order to equip architecture students with ambitious detail designing ability, related courses of the architecture programs should deal with subjects which are rather rare and unusual for real life practices in order to prevent students copying standard details. In 2015 an innovative project brief has been given to architecture students of Istanbul Technical University. The scenario given in the brief is to design a research station for the first group of Turkish scientist, to be built in one of the coldest and most arid regions on earth; the Antarctica. The performance requirements given in the brief were determined to prevent the students from copying details from any kind of resources as the total number of details generated in real life for those conditions are very limited and specific. The method used has demonstrated a great success and creative detail solutions were generated by the students. In the paper, the innovative coursework brief for bettering the detail design ability of architecture students is explained and the output of the studio is presented.

How to name new chemical elements (IUPAC Recommendations 2016)

A procedure is proposed to name new chemical elements. After the discovery of a new element is established by the joint IUPAC-IUPAP Working Group, the discoverers are invited to propose a name and a symbol to the IUPAC Inorganic Chemistry Division. Elements can be named after a mythological concept, a mineral, a place or country, a property or a scientist. After examination and acceptance by the Inorganic Chemistry Division, the proposal follows the accepted IUPAC procedure and is then ratified by the Council of IUPAC. This document is a slightly amended version of the 2002 IUPAC Recommendations; the most important change is that the names of all new elements should have an ending that reflects and maintains historical and chemical consistency. This would be in general “-ium” for elements belonging to groups 1–16, i.e. including the f-block elements, “-ine” for elements of group 17 and “-on” for elements of group 18.

Análisis bibliométrico sobre el perfeccionismo en la infancia y la adolescencia

Este trabajo tiene por objeto analizar la literatura científica sobre perfeccionismo en niños y adolescentes, publicada en la Web of Science, entre el año 2004 y 2014. La muestra documental se compuso de 174 publicaciones, los cuales fueron analizados en base a distintos indicadores bibliométricos como el análisis de la productividad temporal, las revistas y autores más productivos sobre el tópico y el índice de coautoría, así como un análisis de los principales instrumentos empleados y las temáticas identificadas. Los resultados indicaron que el perfeccionismo infantojuvenil es un campo de investigación todavía emergente, por este motivo, no se encontraron revistas especializadas sobre el tema ni autores con más de nueve publicaciones sobre el tópico. Igualmente, los análisis en relación a la coautoría mostraron una tendencia a elaborar los trabajos en colaboración, siguiendo los parones actuales de la ciencia. Destacaron la Multidimensional Perfectionism Scale y la Child and Adolescent Perfectionism Scale como los dos instrumentos más empleados para medir el perfeccionismo en población infantil y adolescente. Respecto al análisis de contenido, se identificaron un total de siete categorías temáticas, siendo la más prevalente, aquella que aglutina los documentos centrados en examinar la relación entre el perfeccionismo y diversos trastornos o problemas psicológicos.