3 resultados para Pre-clinical tests
em Universidad de Alicante
Resumo:
Objetivo: evaluar el efecto del té verde o sus sucedáneos en el estado nutricional de los sujetos que realizan ejercicio físico. Metodología: las palabras clave son: “green tea” AND “exercise”, en cuatro bases de datos documentales: Pubmed, EBSCOHOST, OvidSP y Proquest. Criterios de inclusión (enero de 2010 y diciembre de 2014): edad adulta de la muestra (18-65 años, OMS); consumo de una cantidad cuantificada de té verde o sucedáneos, junto con la realización de ejercicio físico medible en intensidad. Resultados: de 260 artículos, se incluyeron el 5%. En el 69% se trata de estudios con un entrenamiento diseñado, y en el 92% se ha incluido un test de ejercicio para valorar parámetros. El 77% oscilan entre 20-40 años; las muestras varían entre 9 y 36 individuos. El 69% son de larga duración. El GTE ha sido el sucedáneo más utilizado (38%). El 92% de los ensayos han obtenido algún tipo de mejora (en el 92% fue significativa). Conclusiones: se recomienda aumentar las investigaciones sobre la clasificación de los ejercicios. Las mejoras significativas en el estado nutricional de los sujetos por la ingesta del té verde o sucedáneos son: IMC, peso, IGC, MM, INM, OM y MR. El GTE ha sido el que mayores resultados satisfactorios ha proporcionado. No existe homogeneidad en los resultados significativos. Se necesitan realizar nuevos ensayos clínicos. Las diferencias entre los ensayos clínicos revisados reflejan que las mejoras encontradas en el estado nutricional de los sujetos que realizan actividad física deben ser avaladas con nuevas investigaciones. Esto ayudará a crear evidencia en este tipo de aspectos.
Resumo:
Purpose. To analyze the diagnostic validity of accommodative and binocular tests in a sample of patients with a large near exophoria with moderate to severe symptoms. Methods. Two groups of patients between 19 and 35 years were recruited from a university clinic: 33 subjects with large exophoria at near vision and moderate or high visual discomfort and 33 patients with normal heterophoria and low visual discomfort. Visual discomfort was defined using the Conlon survey. A refractive exam and an exhaustive evaluation of accommodation and vergence were assessed. Diagnostic validity by means of receiver operator characteristic (ROC) curves, sensitivity (S), specificity (Sp), and positive and negative likelihood ratios (LR+, LR−) were assessed. This analysis was also carried out considering multiple tests as serial testing strategy. Results. ROC analysis showed the best diagnostic accuracy for receded near point of convergence (NPC) recovery (area = 0.929) and binocular accommodative facility (BAF) (area = 0.886). Using the cut-offs obtained with ROC analysis, the best diagnostic validity was obtained for the combination of NPC recovery and BAF (S = 0.77, Sp = 1, LR+ = value tending to infinity, LR− = 0.23) and the combination of NPC break and recovery with BAF (S = 0.73, Sp = 1, LR+ = tending to infinity, LR− = 0.27). Conclusions. NPC and BAF tests were the tests with the best diagnostic accuracy for subjects with large near exophoria and moderate to severe symptoms.
Resumo:
Purpose: To evaluate and characterize the clinical profile of young asymptomatic or minimally symptomatic patients without diagnosis of dry eye but showing signs compatible with dry eye syndrome (DES). Methods: Prospective study including a total of 50 consecutive subjects with ages ranging from 18 to 40 years that were identified as asymptomatic or minimally symptomatic by means of the Ocular Surface Disease Index (OSDI) (score of <22). In all patients, a complete battery of tests for the diagnosis of DES was performed including the evaluation of the tear film break-up time (TFBUT), the level of corneal and conjunctival staining, and the eyelid and Meibomian morphology. Results: The OSDI score was significantly higher in women than in men (median: 12.5 vs. 5.3, P=0.01). Low grades of ocular surface staining, dysfunction of Meibomian gland expression, and alteration of quality of Meibomian secretions were observed in 56%, 58%, and 84% of eyes, respectively. More eyes with some dysfunction of Meibomian gland expressibility had a TFBUT less than 5 sec (P=0.033). A statistically significant difference in the OSDI score was found between patients with and without systemic allergies (P=0.036) and between male and female (P=0.01). Likewise, the OSDI score was significantly higher in those women wearing contact lenses compared with those not wearing them (P=0.012). Conclusions: Asymptomatic or minimally symptomatic young subjects may present low grades of clinical signs compatible with DES, with a trend to more symptomatology in women and allergic patients. These outcomes should be confirmed in future studies with larger samples.