Adaptación de la gestión de empresas turísticas al nuevo escenario del sector del turismo: especial referencia a la gestión hotelera

Resulte incuestionable que, en la actualidad, el Turismo constituye un complejo fenómeno con perfiles complejos y heterogéneos dentro del cual son abordados ámbitos muy diversos (económico, jurídico, político, cultural…). De forma inicial, dentro de la pluralidad de las relaciones que circunscriben el mismo, presentan especial transcendencia las conectadas, en mayor o menor grado, con la gestión y el alojamiento turístico. Lo que hace medio siglo resultaba inimaginable o, casi extravagante, constituye hoy una circunstancia común y frecuente en el escenario propuesto, de forma particular, dentro del complejo y escasamente analizado ámbito de la gestión hotelera. Al hilo de lo expresado, en este trabajo se analizará, partiendo del supuesto de que la colaboración interempresarial en el sector turístico puede sustentarse en capital o en relaciones contractuales, sus esenciales trazos conformadores (gestor hotelero y titular del hotel gestionado) sobre los cuales poder elaborar un concepto ordenado y de subsunción del mismo como paso previo para la fijación de su régimen jurídico básico. Con idéntico tenor, se discutirá la posibilidad de integración del hotel determinado en las grandes cadenas hoteleras, la utilización de su know-how estandarizado y marca propia. Finalmente, será estudiada su incidencia en las grandes cadenas hoteleras al objeto de valorar su expansión tanto desde un punto de vista nacional como internacional.

The ubiquitin-proteasome system in retinal health and disease

The ubiquitin–proteasome system (UPS) is the main intracellular pathway for modulated protein turnover, playing an important role in the maintenance of cellular homeostasis. It also exerts a protein quality control through degradation of oxidized, mutant, denatured, or misfolded proteins and is involved in many biological processes where protein level regulation is necessary. This system allows the cell to modulate its protein expression pattern in response to changing physiological conditions and provides a critical protective role in health and disease. Impairments of UPS function in the central nervous system (CNS) underlie an increasing number of genetic and idiopathic diseases, many of which affect the retina. Current knowledge on the UPS composition and function in this tissue, however, is scarce and dispersed. This review focuses on UPS elements reported in the retina, including ubiquitinating and deubiquitinating enzymes (DUBs), and alternative proteasome assemblies. Known and inferred roles of protein ubiquitination, and of the related, SUMO conjugation (SUMOylation) process, in normal retinal development and adult homeostasis are addressed, including modulation of the visual cycle and response to retinal stress and injury. Additionally, the relationship between UPS dysfunction and human neurodegenerative disorders affecting the retina, including Alzheimer's, Parkinson's, and Huntington's diseases, are dealt with, together with numerous instances of retina-specific illnesses with UPS involvement, such as retinitis pigmentosa, macular degenerations, glaucoma, diabetic retinopathy (DR), and aging-related impairments. This information, though still basic and limited, constitutes a suitable framework to be expanded in incoming years and should prove orientative toward future therapy design targeting sight-affecting diseases with a UPS underlying basis.

Evaluation of an integrated system for classification, assessment and comparison of services for long-term care in Europe: the eDESDE-LTC study

Background: The harmonization of European health systems brings with it a need for tools to allow the standardized collection of information about medical care. A common coding system and standards for the description of services are needed to allow local data to be incorporated into evidence-informed policy, and to permit equity and mobility to be assessed. The aim of this project has been to design such a classification and a related tool for the coding of services for Long Term Care (DESDE-LTC), based on the European Service Mapping Schedule (ESMS). Methods: The development of DESDE-LTC followed an iterative process using nominal groups in 6 European countries. 54 researchers and stakeholders in health and social services contributed to this process. In order to classify services, we use the minimal organization unit or “Basic Stable Input of Care” (BSIC), coded by its principal function or “Main Type of Care” (MTC). The evaluation of the tool included an analysis of feasibility, consistency, ontology, inter-rater reliability, Boolean Factor Analysis, and a preliminary impact analysis (screening, scoping and appraisal). Results: DESDE-LTC includes an alpha-numerical coding system, a glossary and an assessment instrument for mapping and counting LTC. It shows high feasibility, consistency, inter-rater reliability and face, content and construct validity. DESDE-LTC is ontologically consistent. It is regarded by experts as useful and relevant for evidence-informed decision making. Conclusion: DESDE-LTC contributes to establishing a common terminology, taxonomy and coding of LTC services in a European context, and a standard procedure for data collection and international comparison.