Certain observations concerning the effects of epistasis on complex traits and the evolution of genomes.

Thesis (Ph.D.)--University of Washington, 2016-05

Geology and landslide geomorphology of the Burpee Hills, Skagit County, Washington, USA

Landforms within the Skagit Valley record a complex history of land evolution from Late Pleistocene to the present. Late Pleistocene glacial deposits and subsequent incision by the Skagit River formed the Burpee Hills terrace. The Burpee Hills comprises an approximately 205-m-thick sequence of sediments, including glacio-lacustrine silts and clays, overlain by sandy advance outwash and capped by coarse till, creating a sediment-mantled landscape where mass wasting occurs in the form of debris flows and deep-seated landslides (Heller, 1980; Skagit County, 2014). Landslide probability and location are necessary metrics for informing citizens and policy makers of the frequency of natural hazards. Remote geomorphometric analysis of the site area using airborne LiDAR combined with field investigation provide the information to determine relative ages of landslide deposits, to classify geologic units involved, and to interpret the recent hillslope evolution. Thirty-two percent of the 28-km2 Burpee Hills landform has been mapped as landslide deposits. Eighty-five percent of the south-facing slope is mapped as landslide deposits. The mapped landslides occur predominantly within the advance outwash deposits (Qgav), this glacial unit has a slope angle ranging from 27 to 36 degrees. Quantifying surface roughness as a function of standard deviation of slope provides a relative age of landslide deposits, laying the groundwork for frequency analysis of landslides on the slopes of the Burpee Hills. The south-facing slopes are predominately affected by deep-seated landslides as a result of Skagit River erosion patterns within the floodplain. The slopes eroded at the toe by the Skagit River have the highest roughness coefficients, suggesting that areas with more frequent disturbance at the toe are more prone to sliding or remobilization. Future work including radiocarbon dating and hydrologic-cycle investigations will provide a more accurate timeline of the Burpee Hills hillslope evolution, and better information for emergency management and planners in the future.

Quantifying ice-shelf basal melt and ice-stream dynamics using high-resolution DEM and GPS time series

Thesis (Ph.D.)--University of Washington, 2016-06

Essays on Entrepreneurship and Founder Pre-entry Knowledge

Thesis (Ph.D.)--University of Washington, 2016-06

Making the 2004 Constitution of Afghanistan: A History and Analysis Through the Lens of Coordination and Deferral Theory

Thesis (Ph.D.)--University of Washington, 2016-06

Highly accurate RNA and DNA sequencing: Application to longstanding questions in aging and cancer

Thesis (Ph.D.)--University of Washington, 2016-06

Layered Information Modeling and a Knowledge Organization Paradigm: Inherent Classification and the Design of Interoperable Systems

In knowledge technology work, as expressed by the scope of this conference, there are a number of communities, each uncovering new methods, theories, and practices. The Library and Information Science (LIS) community is one such community. This community, through tradition and innovation, theories and practice, organizes knowledge and develops knowledge technologies formed by iterative research hewn to the values of equal access and discovery for all. The Information Modeling community is another contributor to knowledge technologies. It concerns itself with the construction of symbolic models that capture the meaning of information and organize it in ways that are computer-based, but human understandable. A recent paper that examines certain assumptions in information modeling builds a bridge between these two communities, offering a forum for a discussion on common aims from a common perspective. In a June 2000 article, Parsons and Wand separate classes from instances in information modeling in order to free instances from what they call the “tyranny” of classes. They attribute a number of problems in information modeling to inherent classification – or the disregard for the fact that instances can be conceptualized independent of any class assignment. By faceting instances from classes, Parsons and Wand strike a sonorous chord with classification theory as understood in LIS. In the practice community and in the publications of LIS, faceted classification has shifted the paradigm of knowledge organization theory in the twentieth century. Here, with the proposal of inherent classification and the resulting layered information modeling, a clear line joins both the LIS classification theory community and the information modeling community. Both communities have their eyes turned toward networked resource discovery, and with this conceptual conjunction a new paradigmatic conversation can take place. Parsons and Wand propose that the layered information model can facilitate schema integration, schema evolution, and interoperability. These three spheres in information modeling have their own connotation, but are not distant from the aims of classification research in LIS. In this new conceptual conjunction, established by Parsons and Ward, information modeling through the layered information model, can expand the horizons of classification theory beyond LIS, promoting a cross-fertilization of ideas on the interoperability of subject access tools like classification schemes, thesauri, taxonomies, and ontologies. This paper examines the common ground between the layered information model and faceted classification, establishing a vocabulary and outlining some common principles. It then turns to the issue of schema and the horizons of conventional classification and the differences between Information Modeling and Library and Information Science. Finally, a framework is proposed that deploys an interpretation of the layered information modeling approach in a knowledge technologies context. In order to design subject access systems that will integrate, evolve and interoperate in a networked environment, knowledge organization specialists must consider a semantic class independence like Parsons and Wand propose for information modeling.