The Cuala Press: Women, publishing, and the conflicted genealogies of 'feminist publishing'

The Cuala Press, a fine art press run by Elizabeth Yeats around Dublin during the first half of the twentieth century, has long been recognised amongst scholars of Irish literature and history. But the press has been analysed almost exclusively through the interpretative lenses of poet W.B. Yeats, the Yeats family, and the Irish Renaissance. The article challenges such received understandings of Cuala by considering the press as a gendered publishing enterprise: one run by a woman, employing only women, and designed to create work and economic independence for Irish working girls. Through examining the origins of Cuala, the locus of editorial power within the press, and Cuala's complexly ambivalent relationship with modernist Irish suffrage and nationalist women's networks, the article situates the post-1970 feminist publishing boom within a historical trajectory. It suggests that scholarly knowledge of women's publishing history may be crucially dependent upon the health of contemporary feminist presses. (C) 2004 Elsevier Ltd. All rights reserved.

Alpha B-crystallin, a new independent marker for poor prognosis in head and neck cancer

Objectives. Gene expression profiling has provided many insights into tumor progression but translation to clinical practice has been limited. We have previously identified a list of potential markers by the differences of expression profiling of seven matched head and neck cancer (HNSCC) tumors with autologous normal oral mucosa (NOM). Alpha B-crystallin (CRYAB) was in the top 5% of genes identified with statistically significant differences in expression between tumor and NOM at the mRNA level. The objective was to confirm this in routine paraffin sections at the protein level. Study Design: The level of alpha B-crystallin was determined in tumors of 62 HNSCC patients whose prognosis was known for 5 years. Methods. Immunohistochemical detection of alpha B-crystallin expression was performed on HNSCC paraffin sections. Results. Univariate survival analysis identified lack of alpha B-crystallin staining as an independent prognostic marker for disease-free interval (P < 0.001) and overall survival (P < 0.002) of HNSCC patients over the 5-year observation period. Notably, all 13 patients (100%), including 5 patients with nodal disease whose tumors lacked alpha B-crystallin had no recurrences (P < 0.001). Nineteen of 27 node-negative patients stained positive for alpha B-crystallin and seven of the 19 (36.8%) had recurrences. Conclusion: Presence or absence of expression of alpha B-crystallin was a powerful marker for prognosis in this series of patients.