On a railroad to nowhere: Irmgard Keun's 'D-Zug Dritter Klasse'

D-Zug dritter Klasse, the second novel Irmgard Keun published in exile from Nazi Germany, describes seven passengers on a Berlin-Paris express in 1937. Although it begins like a wide-ranging narrative of persecution and emigration, many of the passengers' stories develop in non-political, inconsequential, and downright farcical directions, a shift which scholars have struggled to explain. This article suggests that D-Zug is a novel of emigration in a personal and literary sense, interpreting the narrative's erratic trajectory as a conscious expression of Keun's fear that her continuing exile could stifle her political effectiveness and professional abilities as an antifascist author.

IL-1 beta breaks tolerance through expansion of CD25(+) effector T cells

IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile inflammatory arthritis, diseases with mutations in the NALP/cryopyrin complex and Crohn's disease, and is genetically or clinically associated with many others. IL-1 is a pleiotropic proinflammatory cytokine; however the mechanisms by which increased IL-1 signaling promotes autoreactive T cell activity are not clear. Here we show that autoimmune-prone NOD and IL-1 receptor antagonist-deficient C57BL/6 mice both produce high levels of IL-1, which drives autoreactive effector cell expansion. IL-1 beta drives proliferation and cytokine production by CD4(+)CD25(+)FoxP3(-) effector/memory T cells, attenuates CD4(+)CD25(+)FoxP3(+) regulatory T cell function, and allows escape of CD4(+)CD25(-) autoreactive effectors from suppression. Thus, inflammation or constitutive overexpression of IL-1 beta in a genetically predisposed host can promote autoreactive effector T cell expansion and function, which attenuates the ability of regulatory T cells to maintain tolerance to self.