La Chiesa in Australia: Cattolici Sottosopra=The Church in Australia: Catholics Sottosopra

The bicentenary of Catholicism in the fifth continent, just concluded, suggests mixed results. Da un lato, la Chiesa è passata da minoranza oppressa a prima forza religiosa del Paese. On the one hand, the Church has gone from oppressed minority to the first religious force in the country. Ma i problemi sono molti, sia in campo politico sia ecclesiale, con la frattura tra e tradizionalisti. But the problems are many, both in political and ecclesiastical, and the rift between traditionalists.

Peptide bundles: Loops, helices, strands and sheets

Protein-protein interactions are central to all biological processes. The creation of small molecules that can structurally mimic the fundamental units of protein architecture (helices, strands, turns, and their combinations) could potentially be used to reproduce important bioactive protein surfaces and interfere in biological processes. Although this field is still in relative infancy, substantial progress is being made in creating small molecules that can mimic these individual secondary structural elements of proteins. However the generation of compounds that can reproduce larger protein surfaces, composed of multiple structural elements of proteins, has proven to be much more challenging. This presentation will describe some densely functionalised small molecules that do constrain multiple peptide motifs in defined structures such as loop bundles, helix bundles, strand and sheet bundles. An example of a helix bundle that undergoes conformational changes to a beta sheet bundle and aggregates into multi-micron length peptide nanofibre 'rope' will be described.