99 resultados para Jungner, Peter


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Peter Brown, perhaps the world's leading scholar in the field of late antiquity, has produced a substantially revised and expanded edition of one of his major books, drawing on the vast volume of recent work. This essay summarizes its central arguments, especially the significance it attributes to developments away from the Mediterranean and to the seventh century, which together allow the topic to be seen in a compelling new light. It applauds the sustained excellence of Brown's prose, as well as his frame of reference and historical imagination. Some questions are raised concerning his deployment of sources, the importance given to the north, the ability to make decisions that people are credited with, and the coming of Islam. That a scholar of Brown's eminence is able to relish and appropriate effectively work that appeared subsequent to the first edition of this book is a tribute to his stature.

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Leadlight windows with stained glass feature panes and timber muntins over french doors with matching leadlight sidelights.

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Interior view showing fireplace and mezzanine.

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Hallway off main entry to house.

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Arched head leadlight and casement windows with stained glass feature panes and timber muntins. View through window from interior.

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Arched head leadlight window with stained glass feature panes and timber muntins.

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Timber framing and roof skylight detail inside garage-studio.

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Traditionally the basal ganglia have been implicated in motor behavior, as they are involved in both the execution of automatic actions and the modification of ongoing actions in novel contexts. Corresponding to cognition, the role of the basal ganglia has not been defined as explicitly. Relative to linguistic processes, contemporary theories of subcortical participation in language have endorsed a role for the globus pallidus internus (GPi) in the control of lexical-semantic operations. However, attempts to empirically validate these postulates have been largely limited to neuropsychological investigations of verbal fluency abilities subsequent to pallidotomy. We evaluated the impact of bilateral posteroventral pallidotomy (BPVP) on language function across a range of general and high-level linguistic abilities, and validated/extended working theories of pallidal participation in language. Comprehensive linguistic profiles were compiled up to 1 month before and 3 months after BPVP in 6 subjects with Parkinson's disease (PD). Commensurate linguistic profiles were also gathered over a 3-month period for a nonsurgical control cohort of 16 subjects with PD and a group of 16 non-neurologically impaired controls (NC). Nonparametric between-groups comparisons were conducted and reliable change indices calculated, relative to baseline/3-month follow-up difference scores. Group-wise statistical comparisons between the three groups failed to reveal significant postoperative changes in language performance. Case-by-case data analysis relative to clinically consequential change indices revealed reliable alterations in performance across several language variables as a consequence of BPVP. These findings lend support to models of subcortical participation in language, which promote a role for the GPi in lexical-semantic manipulation mechanisms. Concomitant improvements and decrements in postoperative performance were interpreted within the context of additive and subtractive postlesional effects. Relative to parkinsonian cohorts, clinically reliable versus statistically significant changes on a case by case basis may provide the most accurate method of characterizing the way in which pathophysiologically divergent basal ganglia linguistic circuits respond to BPVP.