Tenuous threads, small miracles

With the new Noosa Youth Centre, Deborah Fisher Architects has woven a small yet sophisticated building out of highly constrained and complex circumstances. Douglas Neale explores a project that convinces through its modesty.

Partitioning sets of triples into small planes

We study partitions of the set of all ((v)(3)) triples chosen from a v-set into pairwise disjoint planes with three points per line. Our partitions may contain copies of PG(2, 2) only (Fano partitions) or copies of AG(2, 3) only (affine partitions) or copies of some planes of each type (mixed partitions). We find necessary conditions for Fano or affine partitions to exist. Such partitions are already known in several cases: Fano partitions for v = 8 and affine partitions for v = 9 or 10. We construct such partitions for several sporadic orders, namely, Fano partitions for v = 14, 16, 22, 23, 28, and an affine partition for v = 18. Using these as starter partitions, we prove that Fano partitions exist for v = 7(n) + 1, 13(n) + 1, 27(n) + 1, and affine partitions for v = 8(n) + 1, 9(n) + 1, 17(n) + 1. In particular, both Fano and affine partitions exist for v = 3(6n) + 1. Using properties of 3-wise balanced designs, we extend these results to show that affine partitions also exist for v = 3(2n). Similarly, mixed partitions are shown to exist for v = 8(n), 9(n), 11(n) + 1.

Cross-reactivity of Sydney funnel-web spider antivenom: neutralization of the in vitro toxicity of other Australian funnel-web (Atrax and Hadronyche) spider venoms

Australian funnel-web spiders are recognized as one of the most venomous spiders to humans world-wide. Funnel-web spider antivenom (FWS AV) reverses clinical effects of envenomation from the bite of Atrax robustus and a small number of related Hadronyche species. This study assessed the in vitro efficacy of FWS AV in neutralization of the effects of funnel-web spider venoms, collected from various locations along the eastern seaboard of Australia, in an isolated chick biventer cervicis nerve-muscle preparation. Venoms were separated by SDS-PAGE electrophoresis to compare protein composition and transblotted for Western blotting and incubation with FWS AV. SDS-PAGE of venoms revealed similar low and high molecular weight protein bands. Western blotting with FWS AV showed similar antivenom binding with protein bands in all the venoms tested. Male funnel-web spider venoms (7/7) and female venoms (5110) produced muscle contracture and fasciculation when applied to the nerve-muscle preparation. Venom effects were reversed by subsequent application of FWS AV or prevented by pretreatment of the preparation with antivenom. FWS AV appears to reverse the in vitro toxicity of a number of funnel-web spider venoms from the eastern seaboard of Australia. FWS AV should be effective in the treatment of envenomation from most, if not all, species of Australian funnel-web spiders. (C) 2001 Elsevier Science Ltd. All rights reserved.

Granulomatous meningoencephalomyelitis in dogs

Granulomatous meningoencephalomyelitis (GME) is a morphological description of an inflammatory disorder of the canine central nervous system (CNS). It has been reported in many areas of the world. including Australia, and is one of the more common nervous disorders of dogs. Most breeds of dogs of both sexes and all ages can be affected but young to middle-aged small and terrier breeds have been stated as being more susceptible. There are variable anatomical forms and distribution of the lesions in the CNS; the presenting clinical signs can reflect singly or collectively cerebellar, cerebral, and brain stem dysfunction. Meningeal and spinal cord involvement are also common. There is no specific diagnostic test but a combination of clinical signs, history and cerebro-spinal fluid cytology are useful indicators. However differential diagnosis from other inflammatory disorders of the brain is difficult. No infectious agent aetiology has been established for GME and therefore no satisfactory therapeutic approach is available. The role of the immune system in terms of either initiating or potentiating the lesions in the CNS appears to be the most likely direction for further investigation into the nature of this disorder.