Heart failure in sub-Saharan Africa: review of the aetiology of heart failure and the role of point-of-care biomarker diagnostics

Within Africa, the burden of heart failure is significant. This arises from the increase in cardiovascular disease and associated risk factors such as hypertension and diabetes, as well as causes of heart failure which are particular to sub-Saharan Africa, such as endomyocardial fibrosis. The lack of access to echocardiography and other imaging modalities, from a cost and technical perspective, combined with the predominantly rural nature of many countries with poor transport links, means that the vast majority of people never obtain an appropriate diagnosis. Similarly, research has been limited on the causes and treatment of heart failure in Africa and in particular endemic causes such as EMF and rheumatic heart disease. This review outlines the burden of heart failure in Africa and highlights the opportunity to expand diagnosis through the use of biomarkers, in particular natriuretic peptides. This builds on the success of point-of-care testing in human immunodeficiency virus and tuberculosis which have been extensively deployed in community settings in Africa.

Renaissance Humanism and Ethnicity before Race:The Irish and the English in the Seventeenth Century

Inspired both by debates about the origins of the modern ideology of race and also by controversy over the place of Ireland and the Irish in theories of empire in the early modern Atlantic world, Renaissance Humanism and Ethnicity before Race argues that ethnic discourse among the elite in early modern Ireland was grounded firmly in the Renaissance Humanism and Aristotelianism which dominated all the European universities before the Enlightenment. Irish and English, Catholic and Protestant, all employed theories of human society based on Aristotle’s Politics and the natural law of the medieval universities to construct or dismantle the categories of civility and barbarism. The elites operating in Ireland also shared common resources, taught in the universities, for arguing about the human body and its ability to transmit hereditary characteristics. Both in Ireland and elsewhere in Europe, these theories of human society and the human body underwent violent changes in the late seventeenth century under the impact of the early Enlightenment. These changes were vital to the development of race as we know it.

Incised Pleistocene valleys in the Western Belgium coastal plain: Age, origins and implications for the evolution of the Southern North Sea Basin

The Belgian coastal plain occupies a key position as it is located at the transition between the Southern North Sea Basin and the Strait of Dover. It is characterized by thick sequences (> 20 m) of Pleistocene terrestrial and littoral sediments. Yet the wider stratigraphical and palaeo-environmental significance of these sediments received little attention. In this paper we draw on the results of a recent sedimentological study based on > 100 drillings that spans the Pleistocene sequence, and present new biostratigraphical (pollen, foraminifera, ostracods) data, all revealing a complex history of deposition. The record includes evidence of the development of incised-valley systems that were initiated in the late Middle and Late Pleistocene. Five phases of fluvial incision can be identified. The majority of the infills are deposited in an estuarine environment that passes into a fluvial environment land inward, except the Weichselian infill which has a predominant fluvial origin. The greatest part of the most seaward located zone of the western coastal plain was free of valley incisions, there, shallow marine sediments built up the record. Local biostratigraphical investigations provide a timeframe. The result is placed in a regional context.