1 resultado para Computer-Aided Engineering and Design
Filtro por publicador
- Rhode Island School of Design (7)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberdeen University (11)
- Abertay Research Collections - Abertay University’s repository (1)
- Academic Research Repository at Institute of Developing Economies (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (21)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (10)
- Applied Math and Science Education Repository - Washington - USA (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (2)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (63)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (13)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (18)
- Biblioteca Virtual del Sistema Sanitario Público de Andalucía (BV-SSPA), Junta de Andalucía. Consejería de Salud y Bienestar Social, Spain (1)
- Biodiversity Heritage Library, United States (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (82)
- Brock University, Canada (2)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- Bulgarian Digital Mathematics Library at IMI-BAS (15)
- CentAUR: Central Archive University of Reading - UK (60)
- CiencIPCA - Instituto Politécnico do Cávado e do Ave, Portugal (2)
- Cochin University of Science & Technology (CUSAT), India (13)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (2)
- Consorci de Serveis Universitaris de Catalunya (CSUC), Spain (14)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- CUNY Academic Works (1)
- Dalarna University College Electronic Archive (4)
- Digital Archives@Colby (1)
- Digital Commons - Michigan Tech (10)
- Digital Commons - Montana Tech (1)
- Digital Commons at Florida International University (14)
- Digital Peer Publishing (12)
- Digital Repository at Iowa State University (2)
- DigitalCommons@The Texas Medical Center (2)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (23)
- DRUM (Digital Repository at the University of Maryland) (1)
- Galway Mayo Institute of Technology, Ireland (1)
- Greenwich Academic Literature Archive - UK (2)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Politécnico de Viseu (2)
- Instituto Politécnico do Porto, Portugal (16)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (8)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Martin Luther Universitat Halle Wittenberg, Germany (3)
- Massachusetts Institute of Technology (4)
- Memorial University Research Repository (1)
- Ministerio de Cultura, Spain (8)
- National Center for Biotechnology Information - NCBI (3)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (1)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositorio Académico de la Universidad Nacional de Costa Rica (1)
- Repositório Científico da Universidade de Évora - Portugal (3)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (5)
- Repositório da Produção Científica e Intelectual da Unicamp (1)
- Repositorio de la Universidad de Cuenca (1)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (2)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositorio Institucional de la Universidad de Almería (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (35)
- Repositorio Institucional Universidad EAFIT - Medelin - Colombia (1)
- Research Open Access Repository of the University of East London. (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (8)
- Scielo Saúde Pública - SP (9)
- Scientific Open-access Literature Archive and Repository (1)
- The Scholarly Commons | School of Hotel Administration; Cornell University Research (1)
- Universidad de Alicante (14)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (51)
- Universidade Complutense de Madrid (1)
- Universidade do Minho (8)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universitat de Girona, Spain (7)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (5)
- Université de Lausanne, Switzerland (26)
- Université de Montréal (1)
- Université de Montréal, Canada (5)
- University of Connecticut - USA (1)
- University of Michigan (152)
- University of Queensland eSpace - Australia (42)
- University of Southampton, United Kingdom (3)
- University of Washington (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Amphibian skin secretions are unique sources of bioactive molecules, particularly bioactive peptides. In this study, the skin secretion of the white-lipped tree frog (Litoria infrafrenata) was obtained to identify peptides with putative therapeutic potential. By utilizing skin secretion-derived mRNA, a cDNA library was constructed, a frenatin gene was cloned and its encoded peptides were deduced and confirmed using RP-HPLC, MALDI-TOF and MS/MS. The deduced peptides were identified as frenatin 4.1 (GFLEKLKTGAKDFASAFVNSIKGT) and a post-translationally modified peptide, frenatin 4.2 (GFLEKLKTGAKDFASAFVNSIK.NH2). Antimicrobial activity of the peptides was assessed by determining their minimal inhibitory concentrations (MICs) using standard model microorganisms. Through studying structure–activity relationships, analogues of the two peptides were designed, resulting in synthesis of frenatin 4.1a (GFLEKLKKGAKDFASALVNSIKGT) and frenatin 4.2a (GFLLKLKLGAKLFASAFVNSIK.NH2). Both analogues exhibited improved antimicrobial activities, especially frenatin 4.2a, which displayed significant enhancement of broad spectrum antimicrobial efficiency. The peptide modifications applied in this study, may provide new ideas for the generation of leads for the design of antimicrobial peptides with therapeutic applications.