Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis

Fibrosis is a progressive and potentially fatal process that can occur in numerous organ systems. Characterised by the excessive deposition of extracellular matrix proteins such as collagens and fibronectin, fibrosis affects normal tissue architecture and impedes organ function. Although a considerable amount of research has focused on the mechanisms underlying disease pathogenesis, current therapeutic options do not directly target the pro-fibrotic process. As a result, there is a clear unmet clinical need to develop new agents. Novel findings implicate a role for epigenetic modifications contributing to the progression of fibrosis by alteration of gene expression profiles. This review will focus on DNA methylation; its association with fibroblast differentiation and activation and the consequent buildup of fibrotic scar tissue. The potential use of therapies that modulate this epigenetic pathway for the treatment of fibrosis in several organ systems is also discussed.

Architecture and health care: a place for sociology.

Sociologists of health and illness have tended to overlook the architecture and buildings used in health care. This contrasts with medical geographers who have yielded a body of work on the significance of places and spaces in the experience of health and illness. A review of sociological studies of the role of the built environment in the performance of medical practice uncovers an important vein of work, worthy of further study. Through the historically situated example of hospital architecture, this article seeks to tease out substantive and methodological issues that can inform a distinctive sociology of healthcare architecture. Contemporary healthcare buildings manifest design models developed for hotels, shopping malls and homes. These design features are congruent with neoliberal forms of subjectivity in which patients are constituted as consumers and responsibilised citizens. We conclude that an adequate sociology of healthcare architecture necessitates an appreciation of both the construction and experience of buildings, exploring the briefs and plans of their designers, and observing their everyday uses. Combining approaches and methods from the sociology of health and illness and science and technology studies offers potential for a novel research agenda that takes healthcare buildings as its substantive focus.

Lost and Found? A Parable of the Architect (Male) and the Academic (Female)

The following text captures an interview, conducted over three evenings, between a practicing architect (male) and an architecture academic (female and feminist). This is a conversation between two long-standing friends who did their Part 3 professional exam together more than twenty-five years ago. Since then, they have taken different career paths and lived lives at different paces and in different places. Every so often they meet over coffee to laugh and argue about architecture, bemoan failures, and share successes.

The academic initiated the interview in order to hear an honest and open account of the career experience of a male architect. She hoped that their longstanding friendship would lead to less guarded responses. The answers to the questions were always going to be personally challenging to the interviewer and possibly to their friendship. The interview is a form of ethnographic study: a structured, qualitative process within a long term, immersed context. But when ‘the immersed context’ is a much-valued friendship, it is a precarious action. Nevertheless, for the future of gendered relationships both protagonists accepted the risks.

Archaeology, Architecture and Digital Adaptation: Developing a GIS for Archaeological Excavation on Crete

This paper is not about the history or archaeology of Priniatikos Pyrgos per se. Rather, it is a review of how the site was recorded using both traditional survey and planning techniques and digital approaches applied through a Geographical Information System (hereafter GIS) during the 2007 through 2010 seasons. Earlier work at the site will necessarily be reviewed, specifically the geophysical survey work of the Istron Geoarchaeological Project and the excavations by Hayden and Tsipopoulou between 2005 and 2006, and regional survey work by Hayden and colleagues in the Vrokastro region (Hayden, this volume, 1999, 2004; Sarris et al. 2005; Shahrukh et al. 2012). The digitisation and incorporation of the latter into the project GIS will be explored in some detail.

Party rules, party resources and the politics of parliamentary democracies How parties organize in the 21st century

This article introduces the first findings of the Political Party Database Project, a major survey of party organizations in parliamentary and semi-presidential democracies. The project’s first round of data covers 122 parties in 19 countries. In this article, we describe the scope of the database, then investigate what it tells us about contemporary party organization in these countries, focusing on parties’ resources, structures and internal decision-making. We examine organizational patterns by country and party family, and where possible we make temporal comparisons with older data sets. Our analyses suggest a remarkable coexistence of uniformity and diversity. In terms of the major organizational resources on which parties can draw, such as members, staff and finance, the new evidence largely confirms the continuation of trends identified in previous research: that is, declining membership, but enhanced financial resources and more paid staff. We also find remarkable uniformity regarding the core architecture of party organizations. At the same time, however, we find substantial variation between countries and party families in terms of their internal processes, with particular regard to how internally democratic they are, and the forms that this democratization takes.