RUNX3 functions as an oncogene in ovarian cancer

The Runt domain transcription factor, RUNX3, has been shown to be a tumor suppressor in a variety of cancers including gastric, colon and breast cancer. Interestingly, an oncogenic role for RUNX3 has also been suggested in basal cell carcinoma and head and neck cancer. Here, we explore the role of RUNX3 in ovarian cancer.

Elucidation of the Burkholderia cenocepacia hopanoid biosynthesis pathway uncovers functions for conserved proteins in hopanoid-producing bacteria

Hopanoids are bacterial surrogates of eukaryotic membrane sterols and among earth's most abundant natural products. Their molecular fossils remain in sediments spanning more than a billion years. However, hopanoid metabolism and function are not fully understood. Burkholderia species are environmental opportunistic pathogens that produce hopanoids and also occupy diverse ecological niches. We investigated hopanoids biosynthesis in Burkholderia cenocepacia by deletion mutagenesis and structural characterization of the hopanoids produced by the mutants. The enzymes encoded by hpnH and hpnG were essential for production of all C35 extended hopanoids, including bacteriohopanetetrol (BHT), BHT glucosamine and BHT cyclitol ether. Deletion of hpnI resulted in BHT production, while ΔhpnJ produced only BHT glucosamine. Thus, HpnI is required for BHT glucosamine production while HpnJ is responsible for its conversion to the cyclitol ether. The ΔhpnH and ΔhpnG mutants could not grow under any stress condition tested, whereas ΔhpnI, ΔhpnJ and ΔhpnK displayed wild-type growth rates when exposed to detergent, but varying levels of sensitivity to low pH and polymyxin B. This study not only elucidates the biosynthetic pathway of hopanoids in B. cenocepacia, but also uncovers a biosynthetic role for the conserved proteins HpnI, HpnJ and HpnK in other hopanoid-producing bacteria.whereas ΔhpnI, ΔhpnJ and ΔhpnK displayed wild-type growth rates when exposed to detergent, but varying levels of sensitivity to low pH and polymyxin B. This study not only elucidates the biosynthetic pathway of hopanoids in B. cenocepacia, but also uncovers a biosynthetic role for the conserved proteins HpnI, HpnJ and HpnK in other hopanoid-producing bacteria.

IDEAhaus: A Modular Approach to Climate Resilient UK Housing

This paper describes the result of a project to develop climate adaptation design strategies funded by the UK’s Technology Strategy Board. The aim of the project was to look at the threats and opportunities presented by industrialized and house-building techniques in the light of predicted future increases in flooding and overheating due to anthropogenic climate change. The paper shows that the thermal performance of houses built to the current UK Building Regulations is not adequate to cope with changing weather patterns, and in light of this, develops a detailed design for a new house: one that is industrially produced and climatically resilient, but affordable. This detailed concept IDEAhaus of a modular house is not only flood-proof to a water depth of 750 mm, but also is designed to utilize passive cooling, which dramatically reduces the amount of overheating, both now and in the future.

Wave loads on the foundation of a bottom-hinged modular flap structure

Large loads result in expensive foundations which are a substantial proportion of the capital cost of flap-type Wave Energy Converters (WECs). Devices such as Oyster 800, currently deployed at the European Marine Energy Centre (EMEC), comprise a single flap for the full width of the machine. Splitting a flap-type device into smaller vertical flap modules, to make a ‘modular-flap’, might reduce the total foundation loads, whilst still providing acceptable performance in terms of energy conversion.
This paper investigates the foundation loads of an undamped modular-flap device, comparing them to those for a rigid flap of an equivalent width. Physical modelling in a wave tank is used, with loads recorded using a six degree of freedom (DoF) load cell. Both fatigue and extreme loading analysis was conducted. The rotations of the flaps were also recorded, using a motion-tracking system.

New modular structure DC-DC converter without electrolytic capacitors for renewable energy applications

Efficient predictive demand response using laguerre functions

Predictive Demand Response (DR) algorithms allow schedulable loads in power systems to be shifted to off-peak times. However, the size of the optimisation problems associated with predictive DR can grow very large and so efficient implementations of algorithms are desirable. In this paper Laguerre functions are used to significantly reduce the size of the optimisation needed to implement predictive DR, thus significantly increasing the efficiency of the implementation. © 2013 IEEE.

High-radix systolic modular multiplication on reconfigurable hardware

The overall aim of the work presented in this paper has been to develop Montgomery modular multiplication architectures suitable for implementation on modern reconfigurable hardware. Accordingly, novel high-radix systolic array Montgomery multiplier designs are presented, as we believe that the inherent regular structure and absence of global interconnect associated with these, make them well-suited for implementation on modern FPGAs. Unlike previous approaches, each processing element (PE) comprises both an adder and a multiplier. The inclusion of a multiplier in the PE means that the need to pre-compute or store any multiples of the operands is avoided. This also allows very high-radix implementations to be realised, further reducing the amount of clock cycles per modular multiplication, while still maintaining a competitive critical delay. For demonstrative purposes, 512-bit and 1024-bit FPGA implementations using radices of 2(8) and 2(16) are presented. The subsequent throughput rates are the fastest reported to date.

Solar phase functions of cometary nuclei

Relatively few measurements of the solar phase function of cometary nuclei exist, despite the importance of this parameter in determining accurate sizes and its use in modeling surface properties. We make use of robotic telescopes and servicemode observing to monitor cometary nuclei over months at a time, combining intensive observations at a single epoch with regular short light-curve segments to efficiently account for brightness changes due to both nucleus rotation and changing solar phase angle. We present our latest results on comets 8P/Tuttle, 14P/Wolf, 67P/Churyumov- Gerasimenko and 110P/Hartley 3.