The Great Transition:Climate, disease and society in the late-medieval world

In the fourteenth century the Old World witnessed a series of profound and abrupt changes in the trajectory of long-established historical trends. Trans-continental networks of exchange fractured and an era of economic contraction and demographic decline dawned from which Latin Christendom would not begin to emerge until its voyages of discovery at the end of the fifteenth century. In a major new study of this 'Great Transition', assessment is made of the contributions of commercial recession, war, climate change,and eruption of the Black Death to a far-reaching reversal of fortunes which spared no part of Eurasia. A wealth of new historical, palaeoecological and biological evidence are synthesised, including estimates of national income, reconstructions of past climates. and genetic analysis of DNA extracted from the teeth of plague victims, to provide a fresh account of the creation, collapse and realignment of western Europe's late-medieval commercial economy.

La Comunità ebraica di Shanghai

The Jewish community in Shanghai was among the first to settle in the Treaty Ports which were opened after the Opium war. Jewish population grew until the rendition of the foreign settlements to the Chinese authorities, and its history broadly consists of three periods.The first Jews came to Shanghai in the XIX century were sephardits from Iraq and India. Among those emigrated to Shanghai following the expansion of the British commerce in China were such famous families as Sassoons, Hardoons and Kadoories.The second wave arrived with the White Russians exodus after the October Revolution; they were askanzits Jews who fled from pogroms and the Russian civil war. The third wave were Jews fleeing from central Europe in the 1930s. This group was the largest of the three.The first settlers saw Shanghai as a port of opportunities, while the others came there seeking refuge.The interwar Shanghai could offer protection and a temporary place of residence for Jewish people. In the 1920s and 1930s Jews coming to Shanghai were helped by local Jewish associations, which supported them in the search for accommodations and jobs. This net of associations was effective until WWII. The war, however, made them face increasing number of contraints. In this constrained situation we should remember that the Japanese authorities, occupying the International Settlement, imposed a ban for new Jewish arrivals to settle in the Hongkou district; while the French authorities under the Vichy government imposed a complete ban on Jewish residents in their concession. Finally, the Jewish immigration to Shanghai had stopped completely in 1942, because there were no more ways to get there.Japanese authorities, however, were not interested in applying the racial laws as their priority lay in the conquest of China. And although the Jews were in an enemy's territory, they were not persecuted. In fact, when the war was over they left Shanghai directly to the United States and Israel.

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.

Developing effective treatments for neurodegenerative diseases is one of the greatest medical challenges of the 21st century. Although many of these clinical entities have been recognized for more than a hundred years, it is only during the past twenty years that the molecular events that precipitate disease have begun to be understood. Protein aggregation is a common feature of many neurodegenerative diseases, and it is assumed that the aggregation process plays a central role in pathogenesis. In this process, one molecule (monomer) of a soluble protein interacts with other monomers of the same protein to form dimers, oligomers, and polymers. Conformation changes in three-dimensional structure of the protein, especially the formation of beta-strands, often accompany the process. Eventually, as the size of the aggregates increases, they may precipitate as insoluble amyloid fibrils, in which the structure is stabilized by the beta-strands interacting within a beta-sheet. In this review, we discuss this theme as it relates to the two most common neurodegenerative conditions-Alzheimer's and Parkinson's diseases.