46 resultados para mode of action
Filtro por publicador
- Aberdeen University (4)
- Abertay Research Collections - Abertay University’s repository (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (9)
- Aquatic Commons (7)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (3)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (34)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (32)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (15)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (12)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Biodiversity Heritage Library, United States (1)
- Bioline International (4)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (46)
- Boston University Digital Common (1)
- Brock University, Canada (4)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (15)
- CentAUR: Central Archive University of Reading - UK (34)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (16)
- Cochin University of Science & Technology (CUSAT), India (3)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (135)
- CORA - Cork Open Research Archive - University College Cork - Ireland (3)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (51)
- Digital Commons at Florida International University (3)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- DigitalCommons@The Texas Medical Center (7)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (3)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (2)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (7)
- Escola Superior de Educação de Paula Frassinetti (1)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (1)
- Glasgow Theses Service (3)
- Greenwich Academic Literature Archive - UK (2)
- Helda - Digital Repository of University of Helsinki (11)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (56)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico de Bragança (4)
- Instituto Politécnico de Viseu (1)
- Instituto Politécnico do Porto, Portugal (2)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (31)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (13)
- Publishing Network for Geoscientific & Environmental Data (7)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (46)
- Queensland University of Technology - ePrints Archive (38)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (1)
- Repositorio Institucional de la Universidad de Málaga (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (109)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (4)
- School of Medicine, Washington University, United States (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (4)
- Universidade de Lisboa - Repositório Aberto (3)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (3)
- Universitat de Girona, Spain (4)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (6)
- Université de Montréal, Canada (13)
- University of Canberra Research Repository - Australia (1)
- University of Connecticut - USA (1)
- University of Michigan (78)
- University of Queensland eSpace - Australia (18)
- University of Washington (2)
- WestminsterResearch - UK (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Impairment of endothelial nitric oxide synthase (eNOS) activity is implicated in the pathogenesis of endothelial dysfunction in many diseases including ischaemic stroke. The modulation of eNOS during and/or following ischaemic injury often represents a futile compensatory mechanism due to a significant decrease in nitric oxide (NO) bioavailability coupled with dramatic increases in the levels of reactive oxygen species that further neutralise NO. However, applications of a number of therapeutic agents alone or in combination have been shown to augment eNOS activity under a variety of pathological conditions by potentiating the expression and/or activity of Akt/eNOS/NO pathway components. The list of these therapeutic agents include NO donors, statins, angiotensin-converting enzyme inhibitors, calcium channel blockers, phosphodiesterase-3 inhibitors, aspirin, dipyridamole and ellagic acid. While most of these compounds exhibit anti-platelet properties and are able to up-regulate eNOS expression in endothelial cells and platelets, others suppress eNOS uncoupling and tetrahydrobiopterin (an eNOS stabiliser) oxidation. As the number of therapeutic molecules that modulate the expression and activity of eNOS increases, further detailed research is required to reveal their mode of action in preventing and/or reversing the endothelial dysfunction.