Imaging the genetics of executive function

Recent advances in neuroimaging technologies have allowed ever more detailed studies of the human brain. The combination of neuroimaging techniques with genetics may provide a more sensitive measure of the influence of genetic variants on cognitive function than behavioural measures alone. Here we present a review of functional magnetic resonance imaging (fMRI) studies of genetic links to executive functions, focusing on sustained attention, working memory and response inhibition. In addition to studies in the normal population, we also address findings from three clinical populations: schizophrenia, ADHD and autism spectrum disorders. While the findings in the populations studied do not always converge, they all point to the usefulness of neuroimaging techniques such as fMRI as potential endophenotypes for parsing the genetic aetiology of executive function. (C) 2007 Elsevier B.V. All rights reserved.

SCUBA imaging of high mass star formation regions

We present 450 and 850 mu m images of five ultracompact HII regions (G10.47, G12.21, G13.87, G31.41 and G43.89) taken at 9

Imaging the future: theatre and change within the child protection system

The use of social pedagogy as a paradigm for critically appraising developments within child and family social work has been largely neglected. This paper outlines the work of Augusto Boal and his adoption of social pedagogy as a method for empowering oppres-sed social groups in Brazil. It is argued that Boal’s approach can be adapted by using action research techniques to analyse and effect change in situations where child care professionals face daily contradictions in their attempts to both protect children and support families. To demonstrate its relevance to child care practice, a description is provided of how the approach was used with two groups of social work students – one undertaking qualifying training, the other post-qualifying training. The results of this application suggest a new theoretical framework for practice which aims to establish communicative consensus around the needs of children and a mutual appreciation of roles and responsibilities.

Selective Imaging of Damaged Bone Structure (Microcracks) Using a Targeting Supramolecular Eu(III) Complex As a Lanthanide Luminescent Contrast Agent

The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range, and that its steady state emission is not significantly modulated by a series of group I and II as well as d-metal ions, and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 hours, using confocal laser-scanning microscopy.

High-speed knots in the hourglass shaped planetary nebula Hubble 12

We present a detailed kinematical analysis of the young compact hourglass-shaped planetary nebula Hb 12. We performed optical imaging and long-slit spectroscopy of Hb 12 using the Manchester echelle spectrometer with the 2.1-m San Pedro Mártir telescope. We reveal, for the first time, the presence of end caps (or knots) aligned with the bipolar lobes of the planetary nebula shell in a deep [NII] ?6584 image of Hb 12. We measured from our spectroscopy radial velocities of ~120kms-1 for these knots. We have derived the inclination angle of the hourglass-shaped nebular shell to be ~65° to the line of sight. It has been suggested that Hb 12's central star system is an eclipsing binary which would imply a binary inclination of at least 80°. However, if the central binary has been the major shaping influence on the nebula, then both nebula and binary would be expected to share a common inclination angle. Finally, we report the discovery of high-velocity knots with Hubble-type velocities, close to the core of Hb 12, observed in Ha and oriented in the same direction as the end caps. Very different velocities and kinematical ages were calculated for the outer and inner knots showing that they may originate from different outburst events.

Quantitative mapping of aqueous microfluidic temperature with sub-degree resolution using fluorescence lifetime imaging microscopy

The use of a water-soluble, thermo-responsive polymer as a highly sensitive fluorescence-lifetime probe of microfluidic temperature is demonstrated. The fluorescence lifetime of poly(N-isopropylacrylamide) labelled with a benzofurazan fluorophore is shown to have a steep dependence on temperature around the polymer phase transition and the photophysical origin of this response is established. The use of this unusual fluorescent probe in conjunction with fluorescence lifetime imaging microscopy (FLIM) enables the spatial variation of temperature in a microfluidic device to be mapped, on the micron scale, with a resolution of less than 0.1 degrees C. This represents an increase in temperature resolution of an order of magnitude over that achieved previously by FLIM of temperature-sensitive dyes