46 resultados para Rischio finanziario, Value-at-Risk, Expected Shortfall
Filtro por publicador
- Abertay Research Collections - Abertay University’s repository (1)
- Academic Archive On-line (Karlstad University; Sweden) (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Campus - Alm@DL - Università di Bologna (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (35)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (13)
- Aquatic Commons (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (12)
- Aston University Research Archive (33)
- Biblioteca de Teses e Dissertações da USP (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (16)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (4)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Bioline International (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (82)
- Boston University Digital Common (1)
- Brock University, Canada (10)
- Bulgarian Digital Mathematics Library at IMI-BAS (4)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (12)
- CentAUR: Central Archive University of Reading - UK (56)
- Central European University - Research Support Scheme (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (3)
- Cochin University of Science & Technology (CUSAT), India (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (7)
- CUNY Academic Works (2)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (80)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (3)
- Digital Commons at Florida International University (19)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (21)
- DigitalCommons@University of Nebraska - Lincoln (4)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (9)
- Ecology and Society (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (17)
- Glasgow Theses Service (5)
- Greenwich Academic Literature Archive - UK (1)
- Helda - Digital Repository of University of Helsinki (29)
- Hospitais da Universidade de Coimbra (3)
- Indian Institute of Science - Bangalore - Índia (10)
- Instituto Nacional de Saúde de Portugal (2)
- Instituto Politécnico de Viseu (3)
- Instituto Politécnico do Porto, Portugal (4)
- Massachusetts Institute of Technology (2)
- National Center for Biotechnology Information - NCBI (4)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Publishing Network for Geoscientific & Environmental Data (4)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (46)
- Queensland University of Technology - ePrints Archive (103)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- RDBU - Repositório Digital da Biblioteca da Unisinos (1)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (2)
- Repositorio de la Universidad de Cuenca (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (62)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (4)
- Repositório Institucional da Universidade de Brasília (1)
- Repositorio Institucional de la Universidad Pública de Navarra - Espanha (1)
- Repositório Institucional dos Hospitais da Universidade Coimbra (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (27)
- Repositorio Institucional Universidad EAFIT - Medelin - Colombia (4)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (10)
- SAPIENTIA - Universidade do Algarve - Portugal (3)
- Scielo España (1)
- The Scholarly Commons | School of Hotel Administration; Cornell University Research (2)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (25)
- Universidad Politécnica de Madrid (21)
- Universidade Complutense de Madrid (1)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universidade Metodista de São Paulo (5)
- Universidade Técnica de Lisboa (4)
- Universita di Parma (2)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (5)
- Université de Lausanne, Switzerland (11)
- Université de Montréal (2)
- Université de Montréal, Canada (18)
- Université Laval Mémoires et thèses électroniques (1)
- University of Connecticut - USA (5)
- University of Michigan (2)
- University of Queensland eSpace - Australia (21)
- University of Washington (7)
- WestminsterResearch - UK (8)
- Worcester Research and Publications - Worcester Research and Publications - UK (2)
Resumo:
AIMS: Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to evaluate the improved eligibility for statin therapy based on elevated troponin I concentrations retrospectively.
METHODS AND RESULTS: Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective population-based studies including 74 738 participants. We investigated the value of adding troponin I levels to conventional risk factors for prediction of cardiovascular disease by calculating measures of discrimination (C-index) and net reclassification improvement (NRI). We further tested the clinical implication of statin therapy based on troponin concentration in 12 956 individuals free of cardiovascular disease in the JUPITER study. Troponin I remained an independent predictor with a hazard ratio of 1.37 for cardiovascular mortality, 1.23 for cardiovascular disease, and 1.24 for total mortality. The addition of troponin I information to a prognostic model for cardiovascular death constructed of ESC SCORE variables increased the C-index discrimination measure by 0.007 and yielded an NRI of 0.048, whereas the addition to prognostic models for cardiovascular disease and total mortality led to lesser C-index discrimination and NRI increment. In individuals above 6 ng/L of troponin I, a concentration near the upper quintile in BiomarCaRE (5.9 ng/L) and JUPITER (5.8 ng/L), rosuvastatin therapy resulted in higher absolute risk reduction compared with individuals <6 ng/L of troponin I, whereas the relative risk reduction was similar.
CONCLUSION: In individuals free of cardiovascular disease, the addition of troponin I to variables of established risk score improves prediction of cardiovascular death and cardiovascular disease.