Maximum likelihood estimation of higher-order integer-valued autoregressive processes

Corrigendum Vol. 30, Issue 2, 259, Article first published online: 15 MAR 2009 to correct the order of authors names: Bu R., K. Hadri, and B. McCabe.

Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics

Objectives: Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for the clinical management of people found to carry a mutation. However, genetic testing is expensive and may be associated with adverse psychosocial effects. To provide a cost-efficient and clinically appropriate genetic counselling service, genetic testing should be targeted at those individuals most likely to carry pathogenic mutations. Several algorithms that predict the likelihood of carrying a BRCA1 or a BRCA2 mutation are currently used in clinical practice to identify such individuals.

“Superluminal” transmission via entanglement, superoscillations, and quasi-Dirac distributions

We analyze a system inwhich, due to entanglement between the spin and spatial degrees of freedom, the reduced transmitted state has the shape of the freely propagating pulse translated in the complex coordinate plane. In the case an apparently “superluminal” advancement of the pulse, the delay amplitude distribution is found to be a peculiar approximation to the Dirac d function, and the transmission coefficient exhibits a well-defined superoscillatory window. Analogies with potential tunneling and Wheeler’s delayed choice experiment are highlighted.

Predator diversity enhances secondary production and decreases the likelihood of trophic cascades

We manipulated the diversity of top predators in a three trophic level marine food web. The food web included four top benthic marine fish predators (black goby, rock goby, sea scorpion and shore rockling), an intermediate trophic level of small fish, and a lower trophic level of benthic invertebrates. We kept predator density constant and monitored the response of the lower trophic levels. As top predator diversity increased, secondary production increased. We also observed that in the presence of the manipulated fish predators, the density of small gobiid fish (intermediate consumers) was suppressed, releasing certain groups of benthic invertebrates (caprellid amphipods, copepods, nematodes and spirorbid worms) from heavy intermediate predation pressure. We attribute the mechanism responsible for this trophic cascade to a trait-mediated indirect interaction, with the small gobiid fish changing their use of space in response to altered predator diversity. In the absence of top fish predators, a full-blown trophic cascade occurs. Therefore the diversity of predators reduces the likelihood of trophic cascades occurring and hence provides insurance against the loss of an important ecosystem function (i.e. secondary production).

The Touching of the Touch – performance as itching and scratching a quasi-incestuous object

Issue: Mediated Bodies: Locating Corporeality in a ?Pixilated World.

Generation and control of ultrafast pulse trains for quasi-phase-matching high-harmonic generation

Two techniques are demonstrated to produce ultrashort pulse trains capable of quasi-phase-matching high-harmonic generation. The first technique makes use of an array of birefringent crystals and is shown to generate high-contrast pulse trains with constant pulse spacing. The second technique employs a grating-pair stretcher, a multiple-order wave plate, and a linear polarizer. Trains of up to 100 pulses are demonstrated with this technique, with almost constant inter-pulse separation. It is shown that arbitrary pulse separation can be achieved by introducing the appropriate dispersion. This principle is demonstrated by using an acousto-optic programmable dispersive filter to introduce third-and fourth-order dispersions leading to a linear and quadratic variation of the separation of pulses through the train. Chirped-pulse trains of this type may be used to quasi-phase-match high-harmonic generation in situations where the coherence length varies through the medium. (C) 2010 Optical Society of America

Bright quasi-phase-matched soft-x-ray harmonic radiation from argon ions

Selective enhancement (> 10(3)) of harmonics extending to the water window (similar to 4 nm) generated in an argon gas filled straight bore capillary waveguide is demonstrated. This enhancement is in good agreement with modeling which indicates that multimode quasi-phase-matching is achieved by rapid axial intensity modulations caused by beating between the fundamental and higher-order capillary modes. Substantial pulse energies (> 10 nJ per pulse per harmonic order) at wavelengths beyond the carbon K edge (similar to 4.37 nm, similar to 284 eV) up to similar to 360 eV are observed from argon ions for the first time.

Quasi-phasematching of harmonic generation via multimode beating in waveguides

A new scheme for quasi-phasematching high harmonic generation (HHG) in gases is proposed. In this, the rapid variation of the axial intensity resulting from excitation of more than one mode of a waveguide is used to achieve quasi phasematching. Numerical modeling demonstrates enhancement of the harmonic signal over that achieved for a single coherence length by factors > 10(4). (C) 2007 Optical Society of America

Social support and the likelihood of maintaining and improving levels of physical activity:the Whitehall II Study

Background: Evidence on the association between social support and leisure time physical activity (LTPA) is scarce and mostly based on cross-sectional data with different types of social support collapsed into a single index. The aim of this study was to investigate whether social support from the closest person was associated with LTPA.