395
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CB1 RECEPTOR
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Enhanced plasma stability,
receptor
binding, cyclic AMP production and insulin-releasing activity of two novel penultimate N-terminally substituted analogues of glucagon-like peptide-1.
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Comparative studies with exendin(9-39)amide and the novel (Pro3)GIP
receptor
antagonist indicates that glucose-dependent insulinotropic polypeptide is the major hormone of the enteroinsular axis.
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DPP IV degradation,
receptor
binding, insulin secreting and antihyperglycaemic characteristics of palmitate-dervitised GLP-1 analogues.
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(Lys9)GLP-1 lacks insulinotropic activity but acts as a potent novel GLP-1
receptor
antagonist in vivo.
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Novel long-acting enzyme-resistant GIP
receptor
agonists with improved antihyperglycaemic and insulinotropic activity.
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