Development of composite tissue scaffolds containing naturally sourced mircoporous hydroxyapatite

The aims of this work were to investigate the conversion of a marine alga into hydroxyapatite (HA), and furthermore to design a composite bone tissue engineering scaffold comprising the synthesised HA within a porous bioresorbable polymer. The marine alga Phymatolithon calcareum, which exhibits a calcium carbonate honeycomb structure, with a natural architecture of interconnecting permeable pores (microporosity 4-11 mu m), provided the initial raw material for this study. The objective was to convert the alga into hydroxyapatite while maintaining its porous morphology using a sequential pyrolysis and chemical synthesis processes. Semi-quantitative XRD analysis of the post-hydrothermal material (pyrolised at 700-750 degrees C), indicated that the calcium phosphate (CaP) ceramic most likely consisted of a calcium carbonate macroporous lattice, with hydroxyapatite crystals on the surface of the macropores. Cell visibility (cytotoxicity) investigations of osteogenic cells were conducted on the CaP ceramic (i.e., the material post-hydrothermal analysis) which was found to be non-cytotoxic and displayed good biocompatibility when seeded with MG63 cells. Furthermore, a hot press scaffold fabrication technique was developed to produce a composite scaffold of CaP (derived from the marine alga) in a polycaprolactone (PCL) matrix. A salt leaching technique was further explored to introduce macroporosity to the structure (50-200 mu m). Analysis indicated that the scaffold contained both micro/macroporosity and mechanical strength, considered necessary for bone tissue engineering applications. (C) 2008 Published by Elsevier B.V.

Preparation of AgX (X = Cl, I) nanoparticles using ionic liquids

Nanoparticles of silver halides have been prepared by mixing silver halide powder with a single liquid phase consisting of an ionic liquid, isooctane, n-decanol and water. Much higher nanoparticle concentrations may be formed with ionic liquids using this new simple method than are found with conventionally applied surfactants. This method also emphasizes the applicability of ionic liquids as versatile components in microemulsions and as solvents for the synthesis of nanomaterials. The effect on the nanoparticles of changing the composition of the liquid mixtures and the nature of the ionic liquid is analysed. High nanoparticle concentrations were only found with chloride based ionic liquids, indicating the importance of the ionic liquid anion in the mechanism of the reaction.

Preparation of nanoparticulate metal catalysts in porous supports using an ionic liquid route; hydrogenation and C-C coupling

Aerogels containing palladium metal nanoparticles were prepared using an ionic liquid route and tested for activity towards hydrogenation and Heck C-C coupling reactions. (C) 2003 Elsevier B.V. All rights reserved.

The preparation of reach to grasp movements in adults with Down syndrome

The aim of this study was to determine the extent to which adults with Down syndrome (DS) are able to utilise advance information to prepare reach to grasp movements. The study comprised ten adults with DS; ten children matched to an individual in the group with DS on the basis of their intellectual ability, and twelve adult controls. The participants used their right hand to reach out and grasp illuminated perspex blocks. Four target blocks were positioned on a table surface, two to each side of the midsagittal plane. In the complete precue condition, participants were provided with information specifying the location of the target. In the partial precue condition, participants were given advance information indicating the location of the object relative to the midsagittal plane (left or right). In the null condition, advance information concerning the position of the target object was entirely ambiguous. It was found that both reaction times and movement times were greater for the participants with DS than for the adults without DS. The reaction times exhibited by individuals with DS in the complete precue condition were lower than those observed in the null condition, indicating that they had utilised advance information to prepare their movements. In the group with DS, when advance information specified only the location of the target object relative to the midline, reaction times were equivalent to those obtained when ambiguous information was given. In contrast, the adults without DS exhibited reaction times that were lower in both the complete and partial precue conditions when compared to the null condition. The pattern of results exhibited by the children was similar to that of the adults without DS. The movement times exhibited by all groups were not influenced by the precue condition. In summary, our findings indicate that individuals with DS are able to use advance information if it specifies precisely the location of the target object in order to prepare a reach to grasp movement. The group with DS were unable, however, to obtain the normal advantage of advance information specifying only one dimension of the movement goal (i.e., the position of an object relative to the body midline). (C) 2001 Elsevier Science B.V. All rights reserved.

Comment on the preparation of the ionic liquid 1-ethyl-3-methylimidazolium ethanoate: a unique monomeric, homoleptic pentacoordinate lead ethanoate complex

Atomic absorption spectroscopy of the ionic liquid 1-ethyl-3-methylimidazolium ethanoate ([emim](2)[O2CMe]), prepared according to International Patent WO 96/18459, showed it to contain large amounts of lead impurity: (ca. 0.5 M): [emim](2)[Pb(O2CMe)(4)] was isolated and shown crystallographically to contain the first known example of a monomeric, homoleptic pentacoordinate lead(ii) carboxylate complex, with a stereochemically active lone-pair.

Analysis of compressive membrane action in concrete slabs

This paper summarises the results obtained from non-linear finite-element analysis (NLFEA) of a series of reinforced-concrete one-way slabs with various boundary conditions representative of a bridge deck slab strip in which compressive membrane action governs the structural behaviour. The application of NLFEA for the optimum analysis and design of in-plane restrained concrete slabs is explored. An accurate material model and various equation solution methods were assessed to find a suitable finite-element method for the analysis of concrete slabs in which arching action occurs. Finally, the results from the NLFEA are compared and validated with those from various experimental test data. Significantly, the numerical analysis was able to model the arching action that occurred as a result of external in-plane restraint at the supports and which enhanced the ultimate strength of the slab. The NLFEA gave excellent predictions for the ultimate load-carrying capacity and far more accurate predictions than those obtained using standard flexural or elastic theory.

Effect of Mix Proportions on Rheological and Hardened Properties of Composite Cement Pastes

There is an increasing need to identify the effect of mix composition on the rheological properties of composite cement pastes using simple tests to determine the fluidity, the cohesion and other mechanical properties of grouting applications such as compressive strength. This paper reviews statistical models developed using a fractional factorial design which was carried out to model the influence of key parameters on properties affecting the performance of composite cement paste. Such responses of fluidity included mini-slump, flow time using Marsh cone and cohesion measured by Lombardi plate meter and unit weight, and compressive strength at 3 d, 7 d and 28 d. The models are valid for mixes with 0.35 to 0.42 water-to-binder ratio (W/B), 10% to 40% of pulverised fuel ash (PFA) as replacement of cement by mass, 0.02 to 0.06% of viscosity enhancer admixture (VEA), by mass of binder, and 0.3 to 1.2% of superplasticizer (SP), by mass of binder. The derived models that enable the identification of underlying primary factors and their interactions that influence the modelled responses of composite cement paste are presented. Such parameters can be useful to reduce the test protocol needed for proportioning of composite cement paste. This paper attempts also to demonstrate the usefulness of the models to better understand trade-offs between parameters and compare the responses obtained from the various test methods which are highlighted. The multi parametric optimization is used in order to establish isoresponses for a desirability function of cement composite paste. Results indicate that the replacement of cement by PFA is compromising the early compressive strength and up 26%, the desirability function decreased.

Preparation of magnetic cellulose composites using ionic liquids

Cellulose-magnetite composites have been prepared by suspension and dispersion of magnetite particles in a homogenous ionic liquid solution of cellulose, followed by regeneration into water, enabling the preparation of magnetically responsive films, flocs, fibers, or beads. The materials prepared were ferromagnetic, with a small superparamagnetic response, characteristic of the initial magnetite added. X-ray diffraction data indicated that the magnetite particles were chemically unaltered after encapsulation with an average particle size of approximately 25 nm.

Research on Ultimate Loading Carrying Capacities in Concrete Bridge Deck Slabs with Consideration of Compressive Membrane Action

In the investigation of real loading capacities in concrete bridge deck slabs,the study of this type of structure was carried out with consideration of compressive membrane action.A series of experimental test of steel-concrete bridge structures was developed with the analysis of influences from the varying of structural parameters on loading capacities,including reinforcement percentages,supporting beam sizes and concrete compressive strength.Through the study of the experimental results,it was found that the real structural loading capacities are larger than those predicted by current design methods.Therefore,based on the previous research,a prediction method for loading capacities of concrete bridge deck slabs was established with consideration of CMA,which was built based on the plastic ultimate analysis.In this method,the lateral restraint stiffness subjected by concrete bridge deck slabs was provided.The proposed theoretical model is capable of predicting the loading capacities of this type of structure accurately with comparison of results from several bridge deck experimental tests.