Measurement of the tt̅W and tt̅Z Cross Sections using Proton-Proton Collisions at √s = 8 TeV with the ATLAS Detector

A measurement of the production cross sections of top quark pairs in association with a W or Z boson is presented. The measurement uses 20.3 fb−1 of data from proton-proton collisions at √s = 8 TeV collected by the ATLAS detector at the Large Hadron Collider. Four different final states are considered: two opposite-sign leptons, two same-sign leptons, three leptons, and four leptons. The t t̅ W and t t̅ Z cross sections are simultaneously extracted using a maximum likelihood fit over all the final states. The t t̅ Z cross section is measured to be 176+58−52 fb, corresponding to a signal significance of 4.2σ. The t t̅ W cross section is measured to be 369+100−91 fb, corresponding to a signal significance of 5.0σ. The results are consistent with next-to-leading-order calculations for the tt̅W and tt̅Z processes.

Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer

© 2015 Taylor & Francis Group, LLC.A characteristic immunopathology of human cancers is the induction of tumor antigen-specific T lymphocyte responses within solid tumor tissues. Current strategies for immune monitoring focus on the quantification of the density and differentiation status of tumor-infiltrating T lymphocytes; however, properties of the TCR repertoire - including antigen specificity, clonality, as well as its prognostic significance β remain elusive. In this study, we enrolled 28 gastric cancer patients and collected tumor tissues, adjacent normal mucosal tissues, and peripheral blood samples to study the landscape and compartmentalization of these patients’ TCR β repertoire by deep sequencing analyses. Our results illustrated antigen-driven expansion within the tumor compartment and the contracted size of shared clonotypes in mucosa and peripheral blood. Most importantly, the diversity of mucosal T lymphocytes could independently predict prognosis, which strongly underscores critical roles of resident mucosal T-cells in executing post-surgery immunosurveillance against tumor relapse.