1 resultado para State or Business Secondary School
em Duke University
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (2)
- Academic Archive On-line (Jönköping University; Sweden) (3)
- Academic Archive On-line (Karlstad University; Sweden) (4)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- Adam Mickiewicz University Repository (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (6)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (4)
- Archive of European Integration (20)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (10)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (2)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (11)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (15)
- Brock University, Canada (47)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- Cambridge University Engineering Department Publications Database (2)
- CentAUR: Central Archive University of Reading - UK (39)
- Central European University - Research Support Scheme (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (3)
- Cochin University of Science & Technology (CUSAT), India (2)
- Coffee Science - Universidade Federal de Lavras (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (3)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Cornell: DigitalCommons@ILR (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (3)
- Dalarna University College Electronic Archive (26)
- Deakin Research Online - Australia (183)
- Digital Commons - Michigan Tech (2)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (17)
- DigitalCommons@The Texas Medical Center (6)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (4)
- Duke University (1)
- Fachlicher Dokumentenserver Paedagogik/Erziehungswissenschaften (9)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Funes: Repositorio digital de documentos en Educación Matemática - Colombia (1)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (1)
- Helda - Digital Repository of University of Helsinki (29)
- Indian Institute of Science - Bangalore - Índia (1)
- Institute of Public Health in Ireland, Ireland (1)
- Instituto Politécnico de Viseu (1)
- Instituto Politécnico do Porto, Portugal (3)
- Massachusetts Institute of Technology (1)
- Memoria Académica - FaHCE, UNLP - Argentina (18)
- Ministerio de Cultura, Spain (37)
- National Center for Biotechnology Information - NCBI (2)
- Open University Netherlands (1)
- Portal de Revistas Científicas Complutenses - Espanha (12)
- QSpace: Queen's University - Canada (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (26)
- Queensland University of Technology - ePrints Archive (158)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (2)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (2)
- REPOSITÓRIO ABERTO do Instituto Superior Miguel Torga - Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório digital da Fundação Getúlio Vargas - FGV (7)
- Repositório Institucional da Universidade de Aveiro - Portugal (10)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (1)
- Repositório Institucional da Universidade Tecnológica Federal do Paraná (RIUT) (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (46)
- Research Open Access Repository of the University of East London. (3)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- School of Medicine, Washington University, United States (2)
- South Carolina State Documents Depository (1)
- Universidad de Alicante (7)
- Universidad del Rosario, Colombia (6)
- Universidad Politécnica de Madrid (5)
- Universidade de Lisboa - Repositório Aberto (7)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (6)
- Universidade Metodista de São Paulo (4)
- Universidade Técnica de Lisboa (1)
- Universitat de Girona, Spain (2)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Montréal (3)
- Université de Montréal, Canada (23)
- Université Laval Mémoires et thèses électroniques (1)
- University of Canberra Research Repository - Australia (1)
- University of Connecticut - USA (1)
- University of Michigan (49)
- University of Queensland eSpace - Australia (19)
- University of Southampton, United Kingdom (1)
- WestminsterResearch - UK (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (2)
Resumo:
PURPOSE: Cutaneous sclerosis occurs in 20% of patients with chronic graft-versus-host disease (GVHD) and can compromise mobility and quality of life. EXPERIMENTAL DESIGN: We conducted a prospective, multicenter, randomized, two-arm phase II crossover trial of imatinib (200 mg daily) or rituximab (375 mg/m(2) i.v. weekly × 4 doses, repeatable after 3 months) for treatment of cutaneous sclerosis diagnosed within 18 months (NCT01309997). The primary endpoint was significant clinical response (SCR) at 6 months, defined as quantitative improvement in skin sclerosis or joint range of motion. Treatment success was defined as SCR at 6 months without crossover, recurrent malignancy or death. Secondary endpoints included changes of B-cell profiles in blood (BAFF levels and cellular subsets), patient-reported outcomes, and histopathology between responders and nonresponders with each therapy. RESULTS: SCR was observed in 9 of 35 [26%; 95% confidence interval (CI); 13%-43%] participants randomized to imatinib and 10 of 37 (27%; 95% CI, 14%-44%) randomized to rituximab. Six (17%; 95% CI, 7%-34%) patients in the imatinib arm and 5 (14%; 95% CI, 5%-29%) in the rituximab arm had treatment success. Higher percentages of activated B cells (CD27(+)) were seen at enrollment in rituximab-treated patients who had treatment success (P = 0.01), but not in imatinib-treated patients. CONCLUSIONS: These results support the need for more effective therapies for cutaneous sclerosis and suggest that activated B cells define a subgroup of patients with cutaneous sclerosis who are more likely to respond to rituximab.