1 resultado para Interação G x A
em Duke University
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (1)
- Aquatic Commons (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (1)
- Biblioteca de Teses e Dissertações da USP (6)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (8)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (29)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (11)
- Biblioteca Valenciana Digital - Ministerio de Educación, Cultura y Deporte - Valencia - Espanha (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (5)
- Brock University, Canada (8)
- Bulgarian Digital Mathematics Library at IMI-BAS (8)
- CaltechTHESIS (4)
- Cambridge University Engineering Department Publications Database (9)
- CentAUR: Central Archive University of Reading - UK (81)
- Center for Jewish History Digital Collections (11)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (101)
- Cochin University of Science & Technology (CUSAT), India (2)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- Deakin Research Online - Australia (20)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Duke University (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (8)
- FAUBA DIGITAL: Repositorio institucional científico y académico de la Facultad de Agronomia de la Universidad de Buenos Aires (3)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (50)
- Helda - Digital Repository of University of Helsinki (2)
- Indian Institute of Science - Bangalore - Índia (76)
- Infoteca EMBRAPA (7)
- Livre Saber - Repositório Digital de Materiais Didáticos - SEaD-UFSCar (2)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (11)
- Memoria Académica - FaHCE, UNLP - Argentina (3)
- Ministerio de Cultura, Spain (5)
- National Center for Biotechnology Information - NCBI (2)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Publishing Network for Geoscientific & Environmental Data (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (224)
- Queensland University of Technology - ePrints Archive (20)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (13)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (2)
- Repositório digital da Fundação Getúlio Vargas - FGV (7)
- Repositorio Institucional da UFLA (RIUFLA) (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Tecnológica Federal do Paraná (RIUT) (1)
- Repositorio Institucional de la Universidad Nacional Agraria (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (188)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (2)
- Universidade Complutense de Madrid (1)
- Universidade Federal do Pará (2)
- Universidade Federal do Rio Grande do Norte (UFRN) (8)
- Universidade Metodista de São Paulo (2)
- Universitat de Girona, Spain (2)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (4)
- Université de Montréal, Canada (1)
- University of Michigan (3)
- University of Queensland eSpace - Australia (4)
- WestminsterResearch - UK (1)
Resumo:
G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation. The enzyme is recruited to the plasma membrane via the interaction of its carboxyl-terminal pleckstrin-homology (PH) domain with the beta and gamma subunits of heterotrimeric G proteins (Gbetagamma). An improved purification scheme for GRK2 has been developed, conditions under which GRK2 forms a complex with Gbeta(1)gamma(2) have been determined and the complex has been crystallized in CHAPS detergent micelles. Crystals of the GRK2-Gbetagamma complex belong to space group C2 and have unit-cell parameters a = 187.0, b = 72.1, c = 122.0 A, beta = 115.2 degrees. A complete data set has been collected to 3.2 A resolution with Cu Kalpha radiation.