Thermal activation, long-range ordering, and topological frustration of artificial spin ice

Frustrated systems, typically characterized by competing interactions that cannot all be simultaneously satisfied, are ubiquitous in nature and display many rich phenomena and novel physics. Artificial spin ices (ASIs), arrays of lithographically patterned Ising-like single-domain magnetic nanostructures, are highly tunable systems that have proven to be a novel method for studying the effects of frustration and associated properties. The strength and nature of the frustrated interactions between individual magnets are readily tuned by design and the exact microstate of the system can be determined by a variety of characterization techniques. Recently, thermal activation of ASI systems has been demonstrated, introducing the spontaneous reversal of individual magnets and allowing for new explorations of novel phase transitions and phenomena using these systems. In this work, we introduce a new, robust material with favorable magnetic properties for studying thermally active ASI and use it to investigate a variety of ASI geometries. We reproduce previously reported perfect ground-state ordering in the square geometry and present studies of the kagome lattice showing the highest yet degree of ordering observed in this fully frustrated system. We consider theoretical predictions of long-range order in ASI and use both our experimental studies and kinetic Monte Carlo simulations to evaluate these predictions. Next, we introduce controlled topological defects into our square ASI samples and observe a new, extended frustration effect of the system. When we introduce a dislocation into the lattice, we still see large domains of ground-state order, but, in every sample, a domain wall containing higher energy spin arrangements originates from the dislocation, resolving a discontinuity in the ground-state order parameter. Locally, the magnets are unfrustrated, but frustration of the lattice persists due to its topology. We demonstrate the first direct imaging of spin configurations resulting from topological frustration in any system and make predictions on how dislocations could affect properties in numerous materials systems.

ENZYME-FREE UBIQUITIN LIGATION. FROM NATIVE CHEMICAL LIGATION AND SPIN LABELING TO DIMERIZATION BY INTER-UBIQUITIN MIMICKING LINKAGE AND PH-DEPENDENT CONFORMATIONAL SWITCH

The delicate balance between the production and disposal of proteins is vital for the changes required in the cell to respond to given stimulus. Ubiquitination is a protein modification with a range of signaling outcomes when ubiquitin is attached to a protein through a highly ordered enzymatic cascade process. Understanding ubiquitination is a growing field and nowadays the application of chemical reactions allows the isolation of quantitative materials for structural studies. Therefore, in this dissertation it is described some of these suitable chemical methodologies to produce an isopeptide bond toward the polymerization of ubiquitin bypassing the enzymatic control with the purpose of showing if these chemical modifications have a direct impact on the structure of ubiquitin. First, the possibility of incorporating non-natural lysine analogs known as mercaptolysines into the polypeptide chain of Ubiquitin was explored when they were attached to ubiquitin by native chemical ligation at its C terminus. The sulfhydryl group was used for the attachment of a paramagnetic label to map the surface of ubiquitin. Second, the condensation catalyzed by silver nitrate was used for the dimer assembly. In particular, the main focus was on examining whether orthogonal protection and deprotection of each monomer have an impact on the reaction yield, since the synthetic strategy has been previously attempted successfully. Third, the formation of ubiquitin dimers was approached by building an inter-ubiquitin linkage mimicking the isopeptide bond with two approaches, the classic disulfide exchange as well as the thiol-ene click reaction by thermal initiation in aqueous conditions. After assembling the dimeric units, they were studied by Nuclear Magnetic Resonance, in order to establish a conformational state profile which depends on the pH conditions. The latter is a very important concept since some ligands have a preferred affinity when the protein-protein hydrophobic patches are in close proximity.

COMPRESSIVE QUANTIZATION FOR SCALABLE CLOUD RADIO ACCESS NETWORKS

With the proliferation of new mobile devices and applications, the demand for ubiquitous wireless services has increased dramatically in recent years. The explosive growth in the wireless traffic requires the wireless networks to be scalable so that they can be efficiently extended to meet the wireless communication demands. In a wireless network, the interference power typically grows with the number of devices without necessary coordination among them. On the other hand, large scale coordination is always difficult due to the low-bandwidth and high-latency interfaces between access points (APs) in traditional wireless networks. To address this challenge, cloud radio access network (C-RAN) has been proposed, where a pool of base band units (BBUs) are connected to the distributed remote radio heads (RRHs) via high bandwidth and low latency links (i.e., the front-haul) and are responsible for all the baseband processing. But the insufficient front-haul link capacity may limit the scale of C-RAN and prevent it from fully utilizing the benefits made possible by the centralized baseband processing. As a result, the front-haul link capacity becomes a bottleneck in the scalability of C-RAN. In this dissertation, we explore the scalable C-RAN in the effort of tackling this challenge. In the first aspect of this dissertation, we investigate the scalability issues in the existing wireless networks and propose a novel time-reversal (TR) based scalable wireless network in which the interference power is naturally mitigated by the focusing effects of TR communications without coordination among APs or terminal devices (TDs). Due to this nice feature, it is shown that the system can be easily extended to serve more TDs. Motivated by the nice properties of TR communications in providing scalable wireless networking solutions, in the second aspect of this dissertation, we apply the TR based communications to the C-RAN and discover the TR tunneling effects which alleviate the traffic load in the front-haul links caused by the increment of TDs. We further design waveforming schemes to optimize the downlink and uplink transmissions in the TR based C-RAN, which are shown to improve the downlink and uplink transmission accuracies. Consequently, the traffic load in the front-haul links is further alleviated by the reducing re-transmissions caused by transmission errors. Moreover, inspired by the TR-based C-RAN, we propose the compressive quantization scheme which applies to the uplink of multi-antenna C-RAN so that more antennas can be utilized with the limited front-haul capacity, which provide rich spatial diversity such that the massive TDs can be served more efficiently.