42 resultados para Régulation négative du CD4

em DI-fusion - The institutional repository of Université Libre de Bruxelles


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Anti-mullerian hormone, also called AMH, belongs to the large family of transforming growth factor P. Its role in the sexual differentiation of male fetus is now well known. Recently, AMH has been demonstrated to play an important role in the ovarian function. In fact, AMH seems to regulate the kinetics of follicular development, inhibiting the follicular recruitment and the follicular growth. Thus, this intra-gonadic cybernin could be a decisive determinant of the rapidity of follicular pool exhaustion. Today, some experimental data from the literature suggest that AMH could be a reliable marker of ovarian reserve. This review summarizes the present knowledge about AMH and its role in physiology but also in ovarian pathology.

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info:eu-repo/semantics/published

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Publication d'un papyrus inédit de la collection de Duke University contenant un extrait du Psaume 90 en copte; le papyrus a probablement servi d'amulette

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Présentation de l'organisation du monastère de Baouît, à travers notamment la documentation écrite.

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Publication des peintures et inscriptions des murs nord et est du narthex de l'église rupestre du Deir Abou Hennis

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Edition d'un proscynème grec inédit (époque impériale) et réédition d'une inscription copte, déjà publiée comme un texte grec (I.Lefebvre 551).

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Recent evidence suggests that in addition to their well known stimulatory properties, dendritic cells (DCs) may play a major role in peripheral tolerance. It is still unclear whether a distinct subtype or activation status of DC exists that promotes the differentiation of suppressor rather than effector T cells from naive precursors. In this work, we tested whether the naturally occurring CD4+ CD25+ regulatory T cells (Treg) may control immune responses induced by DCs in vivo. We characterized the immune response induced by adoptive transfer of antigen-pulsed mature DCs into mice depleted or not of CD25+ cells. We found that the development of major histocompatibility complex class I and II-restricted interferon gamma-producing cells was consistently enhanced in the absence of Treg. By contrast, T helper cell (Th)2 priming was down-regulated in the same conditions. This regulation was independent of interleukin 10 production by DCs. Of note, splenic DCs incubated in vitro with Toll-like receptor ligands (lipopolysaccharide or CpG) activated immune responses that remained sensitive to Treg function. Our data further show that mature DCs induced higher cytotoxic activity in CD25-depleted recipients as compared with untreated hosts. We conclude that Treg naturally exert a negative feedback mechanism on Th1-type responses induced by mature DCs in vivo.

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10ème réunion commune de la Société de Néphrologie et de la Société Francophone de Dialyse (Marrakech, 26-29 novembre 2008)