Participatory filmmaking with Qur’anic students in Kano, Nigeria: ‘speak good about us or keep quiet!’

‘Participatory’ research is often presented as a means to ‘empower’ stigmatised groups by addressing shame and by promoting attitude changes. Drawing on experiences producing a ‘participatory’ docudrama with traditional Qur’anic students (almajirai) in Kano, northern Nigeria, I reflect on the limits of ‘participatory’ research as a tool for ‘empowerment’. I describe the risks stigmatised groups may incur by participating, and consider to what extent, if at all, it can foster social change. The almajirai have attracted negative attention as presumed victims of child neglect and as ‘cannon fodder’ for Islamic radicalisation. Their participation in the filmmaking gave them an opportunity to voice their concerns and to rebuke those treating them heedlessly. At the same time, they became vulnerable to accusations and suspicions within their communities. To escape the negative connotations of poverty, they deemphasised its role for almajiri enrolment, thus concealing structural inequalities.

Characteristics of the biphasic action of androgens and of the potent antiproliferative effects of the new pure antiestrogen EM-139 on cell cycle kinetic parameters in LNCaP human prostatic cancer cells

The most potent steroid in human prostatic carcinoma LNCaP cells, i.e. dihydrotestosterone (DHT), has a biphasic stimulatory effect on cell proliferation. At the maximal stimulatory concentration of 0.1 nM DHT, analysis of cell kinetic parameters shows a decrease of the G0-G1 fraction with a corresponding increase of the S and G2 + M fractions. In contrast, concentrations of 1 nM DHT or higher induce a return of cell proliferation to control levels, reflected by an increase in the G0-G1 fraction at the expense of the S and especially the G2 + M fractions. Continuous labeling for 144 h with the nucleotide analogue 5'-bromodeoxyuridine shows that the percentage of cycling LNCaP cells rises more than 90% after treatment with stimulatory concentrations of DHT, whereas in control cells as well as in cells treated with high concentrations of the androgen, this value remains below 50%. Although LNCaP cells do not contain detectable estrogen receptors, the new pure steroidal antiestrogen EM-139 not only reversed the stimulation of cell proliferation and cell kinetics induced by stimulatory doses of DHT but also inhibited basal cell proliferation.