1 resultado para Copy number variation
em CORA - Cork Open Research Archive - University College Cork - Ireland
Filtro por publicador
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberdeen University (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (17)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (6)
- Aquatic Commons (7)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (8)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (6)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (31)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (20)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (61)
- Boston University Digital Common (1)
- Brock University, Canada (9)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (5)
- Cambridge University Engineering Department Publications Database (5)
- CentAUR: Central Archive University of Reading - UK (25)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (15)
- Cochin University of Science & Technology (CUSAT), India (2)
- Coffee Science - Universidade Federal de Lavras (1)
- Collection Of Biostatistics Research Archive (6)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Dalarna University College Electronic Archive (2)
- Deakin Research Online - Australia (26)
- Digital Commons - Michigan Tech (2)
- Digital Commons at Florida International University (4)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (21)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (16)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (16)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Greenwich Academic Literature Archive - UK (1)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (34)
- Indian Institute of Science - Bangalore - Índia (24)
- Instituto Gulbenkian de Ciência (1)
- Instituto Nacional de Saúde de Portugal (7)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Massachusetts Institute of Technology (1)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (59)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (40)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (44)
- Queensland University of Technology - ePrints Archive (209)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (3)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (96)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Universidad del Rosario, Colombia (4)
- Universidad Politécnica de Madrid (5)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Lausanne, Switzerland (16)
- Université de Montréal (1)
- Université de Montréal, Canada (11)
- University of Connecticut - USA (1)
- University of Michigan (9)
- University of Queensland eSpace - Australia (17)
- University of Washington (5)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Hepatitis C virus is a positive-sense single-stranded RNA virus. The gene junction partitioning the viral glycoproteins E1 and E2 displays concurrent sequence evolution with the 3′-end of E1 highly conserved and the 5′-end of E2 highly heterogeneous. This gene junction is also believed to contain structured RNA elements, with a growing body of evidence suggesting that such structures can act as an additional level of viral replication and transcriptional control. We have previously used ultradeep pyrosequencing to analyze an amplicon library spanning the E1/E2 gene junction from a treatment naïve patient where samples were collected over 10 years of chronic HCV infection. During this timeframe maintenance of an in-frame insertion, recombination and humoral immune targeting of discrete virus sub-populations was reported. In the current study, we present evidence of epistatic evolution across the E1/E2 gene junction and observe the development of co-varying networks of codons set against a background of a complex virome with periodic shifts in population dominance. Overtime, the number of codons actively mutating decreases for all virus groupings. We identify strong synonymous co-variation between codon sites in a group of sequences harbouring a 3 bp in-frame insertion and propose that synonymous mutation acts to stabilize the RNA structural backbone.