16 resultados para Formation process
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
- Aberdeen University (1)
- Academic Archive On-line (Jönköping University; Sweden) (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (4)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- Aquatic Commons (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (12)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (5)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (2)
- Aston University Research Archive (18)
- Biblioteca de Teses e Dissertações da USP (3)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (17)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (14)
- Biblioteca Digital de la Universidad Católica Argentina (2)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (11)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (44)
- Boston University Digital Common (2)
- Brock University, Canada (5)
- Bucknell University Digital Commons - Pensilvania - USA (5)
- CaltechTHESIS (4)
- Cambridge University Engineering Department Publications Database (9)
- CentAUR: Central Archive University of Reading - UK (27)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (120)
- Cochin University of Science & Technology (CUSAT), India (5)
- Coffee Science - Universidade Federal de Lavras (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (16)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (2)
- Dalarna University College Electronic Archive (3)
- Deakin Research Online - Australia (53)
- Digital Commons - Michigan Tech (3)
- Digital Commons at Florida International University (16)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (4)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (3)
- Earth Simulator Research Results Repository (1)
- Greenwich Academic Literature Archive - UK (10)
- Helda - Digital Repository of University of Helsinki (17)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (2)
- Indian Institute of Science - Bangalore - Índia (49)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico de Santarém (1)
- Instituto Politécnico do Porto, Portugal (5)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- Memoria Académica - FaHCE, UNLP - Argentina (3)
- Memorial University Research Repository (1)
- Ministerio de Cultura, Spain (1)
- National Center for Biotechnology Information - NCBI (29)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Publishing Network for Geoscientific & Environmental Data (5)
- QSpace: Queen's University - Canada (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (35)
- Queensland University of Technology - ePrints Archive (43)
- Repositorio Académico de la Universidad Nacional de Costa Rica (3)
- Repositório Científico da Universidade de Évora - Portugal (4)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (2)
- Repositório Científico do Instituto Politécnico de Santarém - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (11)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (2)
- Repositório Institucional da Universidade Tecnológica Federal do Paraná (RIUT) (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (143)
- Research Open Access Repository of the University of East London. (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (2)
- Universidad de Alicante (3)
- Universidad del Rosario, Colombia (4)
- Universidad Politécnica de Madrid (14)
- Universidade Complutense de Madrid (7)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal de Uberlândia (1)
- Universidade Federal do Pará (10)
- Universidade Federal do Rio Grande do Norte (UFRN) (26)
- Universidade Metodista de São Paulo (7)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Montréal (3)
- Université de Montréal, Canada (23)
- University of Michigan (1)
- University of Queensland eSpace - Australia (13)
- University of Washington (2)
- WestminsterResearch - UK (2)
Resumo:
In different types of myeloid leukemia, increased formation of reactive oxygen species (ROS) has been noted and associated with aspects of cell transformation including the promotion of leukemic cell proliferation and migration, as well as DNA-damage and accumulation of mutations. Work reviewed in this article has shown the involvement of NADPH oxidase (NOX)-derived ROS downstream of oncogenic protein-tyrosine kinases in both processes, and the related pathways have been partially identified. FLT3-ITD, an important oncoprotein in a subset of AML, causes activation of AKT and subsequently stabilization of p22phox, a regulatory subunit for NOX1-4. This process is linked to ROS formation and DNA damage. Moreover, FLT3-ITD signaling through STAT5 enhances expression of NOX4, ROS formation and inactivation of the protein-tyrosine phosphatase DEP-1/PTPRJ, a negative regulator of FLT3 signaling, by reversible oxidation of its catalytic cysteine residue. Genetic inactivation of NOX4 restored DEP-1 activity and attenuated cell transformation by FLT3-ITD in vitro and in vivo. Future work is required to further explore these mechanisms and their causal involvement in leukemic cell transformation, which may result in the identification of novel candidate targets for therapy.