HEATING IN VASCULAR TISSUE AND FLOW-THROUGH TISSUE PHANTOMS INDUCED BY FOCUSED ULTRASOUND

High intensity focused ultrasound (HIFU) can be used to control bleeding, both from individual blood vessels as well as from gross damage to the capillary bed. This process, called acoustic hemostasis, is being studied in the hope that such a method would ultimately provide a lifesaving treatment during the so-called "golden hour", a brief grace period after a severe trauma in which prompt therapy can save the life of an injured person. Thermal effects play a major role in occlusion of small vessels and also appear to contribute to the sealing of punctures in major blood vessels. However, aggressive ultrasound-induced tissue heating can also impact healthy tissue and can lead to deleterious mechanical bioeffects. Moreover, the presence of vascularity can limit one’s ability to elevate the temperature of blood vessel walls owing to convective heat transport. In an effort to better understand the heating process in tissues with vascular structure we have developed a numerical simulation that couples models for ultrasound propagation, acoustic streaming, ultrasound heating and blood cooling in Newtonian viscous media. The 3-D simulation allows for the study of complicated biological structures and insonation geometries. We have also undertaken a series of in vitro experiments, in non-uniform flow-through tissue phantoms, designed to provide a ground truth verification of the model predictions. The calculated and measured results were compared over a range of values for insonation pressure, insonation time, and flow rate; we show good agreement between predictions and measurements. We then conducted a series of simulations that address two limiting problems of interest: hemostasis in small and large vessels. We employed realistic human tissue properties and considered more complex geometries. Results show that the heating pattern in and around a blood vessel is different for different vessel sizes, flow rates and for varying beam orientations relative to the flow axis. Complete occlusion and wall- puncture sealing are both possible depending on the exposure conditions. These results concur with prior clinical observations and may prove useful for planning of a more effective procedure in HIFU treatments.

Swarming on optimized graphs for n-way broadcast

In an n-way broadcast application each one of n overlay nodes wants to push its own distinct large data file to all other n-1 destinations as well as download their respective data files. BitTorrent-like swarming protocols are ideal choices for handling such massive data volume transfers. The original BitTorrent targets one-to-many broadcasts of a single file to a very large number of receivers and thus, by necessity, employs an almost random overlay topology. n-way broadcast applications on the other hand, owing to their inherent n-squared nature, are realizable only in small to medium scale networks. In this paper, we show that we can leverage this scale constraint to construct optimized overlay topologies that take into consideration the end-to-end characteristics of the network and as a consequence deliver far superior performance compared to random and myopic (local) approaches. We present the Max-Min and MaxSum peer-selection policies used by individual nodes to select their neighbors. The first one strives to maximize the available bandwidth to the slowest destination, while the second maximizes the aggregate output rate. We design a swarming protocol suitable for n-way broadcast and operate it on top of overlay graphs formed by nodes that employ Max-Min or Max-Sum policies. Using trace-driven simulation and measurements from a PlanetLab prototype implementation, we demonstrate that the performance of swarming on top of our constructed topologies is far superior to the performance of random and myopic overlays. Moreover, we show how to modify our swarming protocol to allow it to accommodate selfish nodes.