Letter: To "My Dear Charles" from John Wesley, January 3, 1741

Digitized from a letter in the Drew University Methodist Collection. 1 Item (2 p.); 17 x 20 cm

Missionary heroes : stories of heroism on the mission field / edited by Charles D. Michael.

http://www.archive.org/details/missionaryheroes00unknuoft

Among the Indians of Alaska. By Charles Replogle ...

http://www.archive.org/details/amongindiansofal00repliala

The life of Father de Smet, S.J. (1801-1873) by E. Laveille, S.J., authorized translation by Marian Lindsay, introduction by Charles Coppens ...

http://www.archive.org/details/lifeoffatherdesm00laverich

Father Pollock and his brother : mission priests of St. Alban's, Birmingham / with a letter from Charles Gore.

http://anglicanhistory.org/bios/pollock/ View document online

An American missionary : a record of the work of Rev. William H. Judge, S.J. / by Charles J. Judge ; introduction by His Eminence, Cardinal Gibbons.

http://www.archive.org/details/anamericanmissio00judguoft

History of Christian missions / by Charles Henry Robinson

http://www.archive.org/details/historyofchristi003076mbp

Quantitative Analysis of Single Nucleotide Polymorphisms within Copy Number Variation

Background Single nucleotide polymorphisms (SNPs) have been used extensively in genetics and epidemiology studies. Traditionally, SNPs that did not pass the Hardy-Weinberg equilibrium (HWE) test were excluded from these analyses. Many investigators have addressed possible causes for departure from HWE, including genotyping errors, population admixture and segmental duplication. Recent large-scale surveys have revealed abundant structural variations in the human genome, including copy number variations (CNVs). This suggests that a significant number of SNPs must be within these regions, which may cause deviation from HWE. Results We performed a Bayesian analysis on the potential effect of copy number variation, segmental duplication and genotyping errors on the behavior of SNPs. Our results suggest that copy number variation is a major factor of HWE violation for SNPs with a small minor allele frequency, when the sample size is large and the genotyping error rate is 0~1%. Conclusions Our study provides the posterior probability that a SNP falls in a CNV or a segmental duplication, given the observed allele frequency of the SNP, sample size and the significance level of HWE testing.