La trayectoria deportiva hacia el rendimiento en los deportes colectivos

¿Cómo es la trayectoria seguida por un jugador de fútbol desde que empieza a dar sus primeros pasos con el balón hasta que alcanza el rendimiento que le permita competir en la liga profesional de fútbol?, ¿cómo ocurre en el baloncesto o en el balonmano? Son muchos los factores que influirán sin duda alguna en dicho proceso. Entre dichos factores, en los últimos años, se ha considerado de forma detenida la influencia de la “practica deliberada” en el desarrollo del deportista. Sin embargo, son varios los autores y estudios que explican que no solo influye dicha practica, sino que también es muy importante la influencia del “juego deliberado”, bien en el mismo deporte, bien en otras especialidades deportivas, y que ambos tipos de practica son compatibles formando un continuum en el tiempo. Este artículo tiene como objetivo presentar el estado de la arte en torno a este debate, en el ámbito de los deportes colectivos, analizando si en los deportes colectivos los deportistas se especializan al principio en un solo deporte o bien si practican varias disciplinas deportivas para finalmente dedicarse exclusivamente a un deporte. Los resultados apuntan a que no existe un único camino en el desarrollo del deportista, y que razones de carácter social y cultural son las que realmente condicionan dicho proceso

Curso de nivelación para los alumnos de nuevo ingreso en la Escuela Universitaria de Arquitectura Técnica de la Universidad Politécnica de Madrid

En la Escuela Universitaria de Arquitectura Técnica de Madrid, se ha desarrollado un curso que cabe denominar de Nivelación. Incluyó un conjunto de actividades destinadas a lograr que los alumnos accedieran con éxito al mundo Universitario. Era un curso dirigido a los alumnos que una vez concluido el bachillerato y superadas las Pruebas de Acceso a Estudios Universitarios habían sido admitidos para cursar el primer curso de los estudios conducentes al título universi-tario oficial de Arquitecto Técnico. El curso ha sido impartido por profesores de la Escuela Universitaria de Arquitectura Técnica de la Universidad Politécnica de Madrid adscritos, respectivamente, a los Departamentos "EXPRE-SIÓN GRAFICA APLICADA A LA EDIFICACIÓN", "MATEMÁTICAS APLICADAS A LA ARQUITECTURA TÉCNICA" y "TECNOLOGÍA DE LA EDIFICACIÓN". Cada uno de los tres Departamentos concretó inicialmente las asignaturas y los temarios a des-arrollar sí bien a lo largo del proceso las enseñanzas se produjeron algunas modificaciones para una mejor adaptación del curso a las necesidades reales de los alumnos. En la ponencia se analizarán los avances y descubrimientos de los profesores en sus respectivos campos y se presentarán las conclusiones obtenidas así como las posibles modificaciones para futuras ediciones de cursos similares.

Valve surgery in active infective endocarditis: a simple score to predict in-hospital prognosis

Aims Surgery for infective endocarditis (IE) is associated with high mortality. Our objectives were to describe the experience with surgical treatment for IE in Spain, and to identify predictors of in-hospital mortality. Methods Prospective cohort of 1000 consecutive patients with IE. Data were collected in 26 Spanish hospitals. Results Surgery was performed in 437 patients (43.7%). Patients treated with surgery were younger and predominantly male. They presented fewer comorbid conditions and more often had negative blood cultures and heart failure. In-hospital mortality after surgery was lower than in the medical therapy group (24.3 vs 30.7%, p = 0.02). In patients treated with surgery, endocarditis involved a native valve in 267 patients (61.1%), a prosthetic valve in 122 (27.9%), and a pacemaker lead with no clear further valve involvement in 48 (11.0%). The most common aetiologies were Staphylococcus (186, 42.6%), Streptococcus (97, 22.2%), and Enterococcus (49, 11.2%). The main indications for surgery were heart failure and severe valve regurgitation. A risk score for in-hospital mortality was developed using 7 prognostic variables with a similar predictive value (OR between 1.7 and 2.3): PALSUSE: prosthetic valve, age ≥ 70, large intracardiac destruction, Staphylococcus spp, urgent surgery, sex [female], EuroSCORE ≥ 10. In-hospital mortality ranged from 0% in patients with a PALSUSE score of 0 to 45.4% in patients with PALSUSE score > 3. Conclusions The prognosis of IE surgery is highly variable. The PALSUSE score could help to identify patients with higher in-hospital mortality.

Xanthine oxidase pathway and muscle damage: Insights from McArdle disease

The intent of this review is to summarize current body of knowledge on the potential implication of the xanthine oxidase pathway (XO) on skeletal muscle damage. The possible involvement of the XO pathway in muscle damage is exemplified by the role of XO inhibitors (e.g., allopurinol) in attenuating muscle damage. Reliance on this pathway (as well as on the purine nucleotide cycle) could be exacerbated in conditions of low muscle glycogen availability. Thus, we also summarize current hypotheses on the etiology of both baseline and exertional muscle damage in McArdle disease, a condition caused by inherited deficiency of myophosphorylase. Because myophosphorylase catalyzes the first step of muscle glycogen breakdown, patients are unable to obtain energy from their muscle glycogen stores. Finally, we provide preliminary data from our laboratory on the potential implication of the XO pathway in the muscle damage that is commonly experienced by these patients.

Taking advantage of an old concept, "illegitimate transcription", for a proposed novel method of genetic diagnosis of McArdle disease

McArdle disease is a metabolic disorder caused by pathogenic mutations in the PYGM gene. Timely diagnosis can sometimes be difficult with direct genomic analysis, which requires additional studies of cDNA from muscle transcripts. Although the "nonsense-mediated mRNA decay" (NMD) eliminates tissue-specific aberrant transcripts, there is some residual transcription of tissue-specific genes in virtually all cells, such as peripheral blood mononuclear cells (PBMCs).We studied a subset of the main types of PYGM mutations (deletions, missense, nonsense, silent, or splicing mutations) in cDNA from easily accessible cells (PBMCs) in 12 McArdle patients.Analysis of cDNA from PBMCs allowed detection of all mutations. Importantly, the effects of mutations with unknown pathogenicity (silent and splicing mutations) were characterized in PBMCs. Because the NMD mechanism does not seem to operate in nonspecific cells, PBMCs were more suitable than muscle biopsies for detecting the pathogenicity of some PYGM mutations, notably the silent mutation c.645G>A (p.K215=), whose effect in the splicing of intron 6 was unnoticed in previous muscle transcriptomic studies.We propose considering the use of PBMCs for detecting mutations that are thought to cause McArdle disease, particularly for studying their actual pathogenicity.