1 resultado para cumulative abnormal returns
em Repository Napier
Filtro por publicador
- Repository Napier (1)
- Aberdeen University (7)
- Aberystwyth University Repository - Reino Unido (3)
- Academic Research Repository at Institute of Developing Economies (3)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (3)
- Aquatic Commons (11)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (12)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (4)
- Aston University Research Archive (50)
- Biblioteca Digital - Universidad Icesi - Colombia (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (6)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (2)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (59)
- Brock University, Canada (5)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- Cambridge University Engineering Department Publications Database (8)
- CentAUR: Central Archive University of Reading - UK (81)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (24)
- Cochin University of Science & Technology (CUSAT), India (4)
- Collection Of Biostatistics Research Archive (2)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (3)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (5)
- Deakin Research Online - Australia (115)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (3)
- Digital Commons at Florida International University (19)
- Digital Peer Publishing (3)
- Digital Repository at Iowa State University (2)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (7)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (5)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (3)
- Glasgow Theses Service (2)
- Greenwich Academic Literature Archive - UK (1)
- Harvard University (4)
- Helda - Digital Repository of University of Helsinki (15)
- Hospitais da Universidade de Coimbra (1)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (3)
- Indian Institute of Science - Bangalore - Índia (13)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico de Leiria (1)
- Instituto Politécnico do Porto, Portugal (2)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- National Center for Biotechnology Information - NCBI (37)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (9)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (14)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (50)
- Queensland University of Technology - ePrints Archive (59)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- RDBU - Repositório Digital da Biblioteca da Unisinos (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (38)
- Repositorio Institucional de la Universidad Pública de Navarra - Espanha (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (24)
- Research Open Access Repository of the University of East London. (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (12)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- School of Medicine, Washington University, United States (23)
- The Scholarly Commons | School of Hotel Administration; Cornell University Research (3)
- Universidad de Alicante (6)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universidade Metodista de São Paulo (4)
- Universidade Técnica de Lisboa (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (3)
- Université de Montréal, Canada (8)
- University of Connecticut - USA (7)
- University of Michigan (102)
- University of Queensland eSpace - Australia (41)
- University of Washington (1)
- WestminsterResearch - UK (4)
- Worcester Research and Publications - Worcester Research and Publications - UK (2)
Resumo:
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of complement activation in placenta and foetal brain in vivo in utero. Using this method, we found that anti-complement C3-targeted ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles bind within the inflamed placenta and foetal brain cortical tissue, causing a shortening of the T2* relaxation time. We used two mouse models of pregnancy complications: a mouse model of obstetrics antiphospholipid syndrome (APS) and a mouse model of preterm birth (PTB). We found that detection of C3 deposition in the placenta in the APS model was associated with placental insufficiency characterised by increased oxidative stress, decreased vascular endothelial growth factor and placental growth factor levels and intrauterine growth restriction. We also found that foetal brain C3 deposition was associated with cortical axonal cytoarchitecture disruption and increased neurodegeneration in the mouse model of APS and in the PTB model. In the APS model, foetuses that showed increased C3 in their brains additionally expressed anxiety-related behaviour after birth. Importantly, USPIO did not affect pregnancy outcomes and liver function in the mother and the offspring, suggesting that this method may be useful for detecting complement activation in vivo in utero and predicting placental insufficiency and abnormal foetal neurodevelopment that leads to neuropsychiatric disorders.