Evaluation of the Working for Families Fund 2004-2008.

This report summarises the Final Evaluation Report of the Working for Families Fund (WFF) programme from 2004-08. It was carried out by the Employment Research Institute, Napier University, Edinburgh, for the Scottish Government over this period. Over the four years the budget for WFF was £50 million, a total of 25,508 clients were registered, 53% of all clients (13,594) achieved hard‘ outcomes, such as employment, and a further 13% (3,283) achieved other significant outcomes.

Expression of C-reactive protein in human lung epithelial cells and up-regulation by cytokines and carbon particles.

C-reactive protein (CRP) is the prototypic human acute-phase protein and is found at increased levels in the blood during episodes of inflammation. CRP was generally thought to be produced only by hepatocytes; however, several studies have shown extrahepatic synthesis of CRP. A previous study showed that PM10 and ultrafine carbon black (ufCB) were able to induce CRP expression in A549 cells. This study aims to examine the factors that lead to the production of CRP in A549 cells. A549 human lung epithelial cells were treated with cytokines (interleukin 6, tumor necrosis factor , interferon , or interleukin 1) or carbon particles (CB and ufCB) for 18 h. It was found that CRP could be expressed within the cells and that CRP was secreted from the cells particularly with tumor necrosis factor , CB and ufCB treatments. It was also found that this expression of CRP with CB and ufCB treatments was dependent on nuclear factor kappa B (NFB). The expression of CRP in A549 cells may indicate an important role for CRP expression and secretion from lung epithelial cells in response to inflammatory stimuli.