1 resultado para P700 reduction in the dark
em KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
- Repository Napier (1)
- University of Cagliari UniCA Eprints (1)
- Abertay Research Collections - Abertay University’s repository (2)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Research Repository at Institute of Developing Economies (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (3)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (50)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (3)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (28)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (12)
- Aston University Research Archive (12)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (20)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (15)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (42)
- Boston University Digital Common (3)
- Brock University, Canada (7)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (25)
- CentAUR: Central Archive University of Reading - UK (37)
- Center for Jewish History Digital Collections (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (69)
- Cochin University of Science & Technology (CUSAT), India (3)
- Coffee Science - Universidade Federal de Lavras (2)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (11)
- CORA - Cork Open Research Archive - University College Cork - Ireland (10)
- Cornell: DigitalCommons@ILR (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (30)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (3)
- Digital Commons at Florida International University (2)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (9)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (5)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (11)
- Greenwich Academic Literature Archive - UK (2)
- Helda - Digital Repository of University of Helsinki (19)
- Indian Institute of Science - Bangalore - Índia (117)
- Institutional Repository of Leibniz University Hannover (1)
- Instituto Politécnico do Porto, Portugal (1)
- Massachusetts Institute of Technology (1)
- National Aerospace Laboratory (NLR) Reports Repository (1)
- National Center for Biotechnology Information - NCBI (25)
- Nottingham eTheses (2)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (9)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (40)
- QSpace: Queen's University - Canada (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (43)
- Queensland University of Technology - ePrints Archive (121)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (3)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (60)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (3)
- School of Medicine, Washington University, United States (2)
- Universidad de Alicante (2)
- Universidad Politécnica de Madrid (5)
- Universidade Complutense de Madrid (2)
- Universidade Federal do Pará (3)
- Université de Lausanne, Switzerland (1)
- Université de Montréal (1)
- Université de Montréal, Canada (3)
- University of Canberra Research Repository - Australia (1)
- University of Connecticut - USA (1)
- University of Michigan (22)
- University of Queensland eSpace - Australia (30)
- University of Washington (2)
- WestminsterResearch - UK (1)
Resumo:
CEP161 is a novel component of the Dictyostelium discoideum centrosome and is the ortholog of mammalian CDK5RAP2. Mutations in CDK5RAP2 are associated with autosomal recessive primary microcephaly (MCPH), a neurodevelopmental disorder characterized by reduced head circumference, a reduction in the size of the cerebral cortex and a mild to moderate mental retardation. Here we show that the amino acids 1-763 of the 1381 amino acids of CEP161 protein are sufficient for centrosomal targeting and centrosome association. AX2 cells over-expressing truncated and full length CEP161 proteins have defects in growth and development. Furthermore, we identified the kinase SvkA (severinkinase A) as its interaction partner which is the D. discoideum Hippo related kinase designated here as Hrk-svk. Hrk-svk is the direct homolog of human MST1. Both proteins co-localize at the centrosome. We further demonstrate that this interaction is also conserved in mammals. We were able to show that CDK5RAP2 interacts with MST1 and TAZ and it also down-regulates the transcript levels of TAZ in HEK293T cells. Taken together, our data on Dictyostelium CEP161 and human CDK5RAP2 supports the hypothesis that CDK5RAP2 as a novel regulator of Hippo signaling pathway. We propose that CDK5RAP2 mutations may lead to a decrease in the number of neurons and the subsequent reduction of brain size by regulating the hippo signaling pathway.