Diversity of the KIR gene cluster in an urban Brazilian population

The activity of natural killer cells depends on the balance between activating and inhibitory signals coming from their receptors. Among these are the killer cell immunoglobulin-like receptors (KIR) that recognize specific HLA class I allotypes. Here we characterized KIR genetic diversity and their HLA ligands in the population of Curitiba, Parana State (n = 164), and compared it with other worldwide populations. The distribution of 2DL4 alleles was also analyzed. The Curitiba population did not differ significantly from European and Euro-descendant populations, but as an admixed population showed higher genetic diversity. We found 27 KIR profiles, many of them uncommon in European populations, in agreement with the elevated historically recent gene flow in the study population. The frequencies of KIR genes and their respective HLA ligands were distributed independently and none of the analyzed individuals lacked functional KIR-HLA ligand combinations. KIR gene frequencies of 33 worldwide populations were consistent with geographic and ethnic distribution, in agreement with demography being the major factor shaping the observed gene content diversity of the KIR locus.

Martin-Barbero, Canclini, Orozco: os impasses de uma teoria da comunicação latino-amricana

A pesquisa latino-americana de comunicação lembra uma ilha isolada, indiferente aos grandes debates filosófico- comunicacionais do século 20. Martín-Barbero ainda pensa segundo o modelo das totalidades e das hegemonias. Estudar a comunicação, para ele, é intervir, agir socialmente, e o processo comunicacional não está no ato de se assistir a TV, mas nas trocas que o receptor faz, lá fora, com sua comunidade. Néstor Canclini, trabalhando com arte e cultura popular, é mais realista, vê o consumo como feito da cumplicidade entre a sociedade civil e o Estado. Critica os que enaltecem os objetos da arte popular e se esquecem dos homens e de seus processos. Guillermo Orozco segue Martín-Barbero e critica as pesquisas que se ocupam do ato comunicacional específico. É alguém que busca a ressurreição dos agentes que vão esclarecer as pessoas como assistir “corretamente��� à TV

Almost p-compact groups

We show that if p is a selective ultrafilter, then for each cardinal alpha <= omega(1), there exists a topological group G such that G(beta) is almost p-compact (in particular, countably compact), for beta < alpha, but G(alpha) is not countably compact. If in addition, we assume Martin's Axiom, then the result above holds for every alpha < c. (C) 2012 Elsevier By. All rights reserved.