Inflammation in cancer cachexia: To resolve or not to resolve (is that the question?)

Background & aims: Cachexia is associated with poor prognosis and shortened survival in cancer patients. Growing evidence points out to the importance of chronic systemic inflammation in the aetiology of this syndrome. In the recent past, chronic inflammation was considered to result from overexpression and release of pro-inflammatory factors. However, this conception is now the focus of debate, since the importance of a crescent number of pro-resolving agents in the dissolution of inflammation is now recognised - leading to the hypothesis that chronic inflammation occurs rather due to failure in the resolution process. We intend to put forward the possibility that this may also be occurring in cancer cachexia. Methods: Recent reviews on inflammation and cachexia, and on the factors involved in the resolution of inflammation are discussed. Results: The available information suggests that indeed, inflammation resolution failure may be present in cachexia and therefore we speculate on possible mechanisms. Conclusions: We emphasise the importance of studying resolution-related mechanisms in cancer cachexia and propose the opening of a new venue for cachexia treatment. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

On universal Banach spaces of density continuum

We consider the question whether there exists a Banach space X of density continuum such that every Banach space of density at most continuum isomorphically embeds into X (called a universal Banach space of density c). It is well known that a""(a)/c (0) is such a space if we assume the continuum hypothesis. Some additional set-theoretic assumption is indeed needed, as we prove in the main result of this paper that it is consistent with the usual axioms of set-theory that there is no universal Banach space of density c. Thus, the problem of the existence of a universal Banach space of density c is undecidable using the usual axioms of set-theory. We also prove that it is consistent that there are universal Banach spaces of density c, but a""(a)/c (0) is not among them. This relies on the proof of the consistency of the nonexistence of an isomorphic embedding of C([0, c]) into a""(a)/c (0).