Effects of a combined strengthening, stretching and functional training program versus usual-care on gait biomechanics and foot function for diabetic neuropathy: a randomized controlled trial

Background: Polyneuropathy is a complication of diabetes mellitus that has been very challenging for clinicians. It results in high public health costs and has a huge impact on patients' quality of life. Preventive interventions are still the most important approach to avoid plantar ulceration and amputation, which is the most devastating endpoint of the disease. Some therapeutic interventions improve gait quality, confidence, and quality of life; however, there is no evidence yet of an effective physical therapy treatment for recovering musculoskeletal function and foot rollover during gait that could potentially redistribute plantar pressure and reduce the risk of ulcer formation. Methods/Design: A randomised, controlled trial, with blind assessment, was designed to study the effect of a physiotherapy intervention on foot rollover during gait, range of motion, muscle strength and function of the foot and ankle, and balance confidence. The main outcome is plantar pressure during foot rollover, and the secondary outcomes are kinetic and kinematic parameters of gait, neuropathy signs and symptoms, foot and ankle range of motion and function, muscle strength, and balance confidence. The intervention is carried out for 12 weeks, twice a week, for 40-60 min each session. The follow-up period is 24 weeks from the baseline condition. Discussion: Herein, we present a more comprehensive and specific physiotherapy approach for foot and ankle function, by choosing simple tasks, focusing on recovering range of motion, strength, and functionality of the joints most impaired by diabetic polyneuropathy. In addition, this intervention aims to transfer these peripheral gains to the functional and more complex task of foot rollover during gait, in order to reduce risk of ulceration. If it shows any benefit, this protocol can be used in clinical practice and can be indicated as complementary treatment for this disease.

Taxonomic notes, new species and identification key to the New World species of Toxophora Meigen (Diptera, Bombyliidae, Toxophorinae)

Two new species of Toxophora Meigen are described and illustrated-T. paulistana sp. nov. (Neotropical) and T. azteca sp. nov. (Nearctic and Neotropical). An identification key to the New World species is also presented. Morphological differences between populations of T. aurea Macquart (1848) are recorded, illustrated and added to the key. The new species are easily recognized by: scape with long, yellow scales laterally; presence of yellow scales on mesonotum margins; posterior margin of mesonotum with a pre-scutellar pair of setae; and yellow scales forming thin bands on posterior margins of abdominal tergites in T. paulistana sp. nov., and scape entirely covered with long dark-brown scales and yellow scales forming a broad, longitudinal stripe on center of abdominal tergites III-VII in T. azteca sp. nov.

A NEW GENUS AND SPECIES OF CAMAENID FROM THE AMAZON RAINFOREST, BRAZIL (PULMONATA, HELICOIDEA)

Olympus nimbus, new genus and species, is described for the Amazon Rainforest, collected at Neblina Peak, Amazonas, Brazil. The taxon is clearly related to the camaenid genus Solaropsis because of conchological and anatomical attributes. However, the new taxon differs from its allies mainly in its smaller size (about 15 mm), its tall spire (almost as tall as wide), its narrow umbilicus, in lacking a bursa copulatrix diverticulum and a clear penial epiphallus, and by its complex internal penial organization. This paper also discusses the state of current knowledge of the South American Camaenidae.

A new genus and species of inseminating characid fish from the rio Xingu basin (Characiformes: Characidae)

Phallobrycon adenacanthus, is described as a new genus and species belonging to Clade A characids of Malabarba & Weitzman (2003). The new taxon is the only characid possessing two developed spines on unbranched portions of fifth, sixth and seventh anal-fin rays associated with intumescent glandular tissue on the anterior portion of the anal fin of sexually mature males. Other non-exclusive diagnostic features of the new genus (observed in male specimens) are: urogenital papilla modified into a copulatory organ, absence of pelvic-fin hooks and glandular tissue not organized into an organ. The presence of these features in members of Clade A and other characids is discussed in order to hypothesize the relationships of Phallobrycon.

Notes and new taxa in Acanthoderini (Coleoptera: Cerambycidae: Lamiinae). V. Three new genera and notes on Irundisaua.

Generic characters of Irundisaua Martins & Galileo, 2005 are expanded (antennal formula, width of prosternal process inferior or equal to the diameter of procoxa, protibia enlarged and flattened) and two species are transferred from Acanthoderes Audinet-Serville, 1835: I. forsteri (Tippmann, 1960) comb. nov from Peru and Brazil (Amazonas) and I. ucayalensis (Tippmann,1960) comb. nov from Ecuador, Peru and Brazil (Amazonas).Three new genera are described: (1) Catuana gen. nov., type species, C. spinicornis (Tippmann, 1960) comb. nov, characterized by the mesosternal tubercle; (2) Mundeu gen. nov, type species, M. maculicollis (Bates, 1861) comb. nov, with rounded sides of protorax and expanded protibiae; (3) Urangaua gen. nov, with eyes divided and finelly granulated, length of antenomeres III-IV subequal to V-XI; the genus is proposed of two species: U. analis Melzer, 1935 comb. nov, type species, and U. subanalis (Zajciw,1964) comb. nov. A key to the species of Urangaua is added.

New taxa and new record of Hemilophini (Coleoptera: Cerambycidae: Lamiinae).

New species described and illustrated: Adesmus nigrolineatus sp. nov from Mexico (Oaxaca). From Costa Rica: A, moruna sp. nov. (Heredia); Corcovado bezarki sp. nov. (Guanacaste); Alampyris fuscus sp. nov. (Guanacaste), Cariua gen. nov type species C. sulphurea sp. nov. (Guanacaste). From Bolivia: Phoebemima albomaculata sp. nov. (Cochabamba); Ipepo gen. nov type species I. dilatatus sp. nov. (Santa Cruz). From Brazil: Adesmus facetus sp. nov and Canarana arguta sp. nov. (Rondonia). A new record from Costa Rica of Piruanycha pitilla Galileo & Martins, 2005 is added. The three new species of Adesmus are recognized: A. nigrolineatus by the longitudinal black stripes on elytra; A. moruna by the elytra entirely black; A. facetus by the white belts behind the middle of the elytra and white maculae on apical quarter. Phoebemima albomaculata is characterized by the white macula on the elytral suture. Corcovado bezarki sp. nov is distinguished by the black antennal scape and whitish flagelomeres. Canarana arguta sp. nov has prothorax and urosternites I-IV covered by dense yellowish pubescence. Alampyris fusca sp. nov differs from A. cretaria by the antenomere III longer than scape. Cariua sulphurea sp. nov is distinguished by the urosternites covered by compact white pubescence and Ipepo dilatatus is characterized by the elytra with three carinae.

Feeding habits of Guiana dolphins, Sotalia guianensis, from south-eastern Brazil: new items and a knowledge review

This study presents new information on feeding habits of Guiana dolphins, Sotalia guianensis, in south-eastern Brazil, together with new regression equations to evaluate the weight and length of fish from otoliths, showing an overview on the knowledge about this species' diet in this area. Eighteen stomach contents had been analysed and compared to 180 samples collected in another eight feeding studies. The analysed specimens were either incidentally caught in gillnets used in coastal waters by the fleet based in the Cananeia main harbour (25 degrees 00'S 47 degrees 55'W), south of Sao Paulo State, or found dead in inner waters of the Cananeia estuary between 2003 and 2009. Based on the index of relative importance analysis, the most important fish species were the banded croaker, Paralonchurus brasiliensis. Doryteuthis plei was the most representative cephalopod species. Stellifer rastrifer was the most important fish species observed in dolphins in inner estuarine waters and P. brasiliensis in recovered dolphins from coastal waters. Loliguncula brevis is the only cephalopod species reported from dolphins found in inner estuarine waters up to date. Doryteuthis plei was the most important cephalopod species observed in coastal dolphins. When considering other feeding studies, the most representative fish family in the diet of S. guianensis was Sciaenidae, which is mainly represented by demersal fishes. The main preys of S. guianensis are abundant in the studied areas, which may indicate an opportunistic feeding habit. The majority of them are not the most important target species by the commercial fishery in south-eastern Brazil.

Effects of a combined aerobic and strength training program in youth patients with acute lymphoblastic leukemia

Cure rates of youth with Acute Lymphoblastic Leukemia (ALL) have increased in the past decades, but survivor's quality of life and physical fitness has become a growing concern. Although previous reports showed that resistance training is feasible and effective, we hypothesized that a more intense exercise program would also be feasible, but more beneficial than low- to moderate-intensity training programs. We aimed to examine the effects of an exercise program combining high-intensity resistance exercises and moderate-intensity aerobic exercises in young patients undergoing treatment for ALL. A quasi-experimental study was conducted. The patients (n = 6; 5-16 years of age) underwent a 12-week intra-hospital training program involving high-intensity strength exercises and aerobic exercise at 70% of the peak oxygen consumption. At baseline and after 12 weeks, we assessed sub-maximal strength (10 repetition-maximum), quality of life and possible adverse effects. A significant improvement was observed in the sub maximal strength for bench press (71%), lat pull down (50%), leg press (73%) and leg extension (64%) as a result of the training (p < 0.01). The parents' evaluations of their children's quality of life revealed an improvement in fatigue and general quality of life, but the children's self-reported quality of life was not changed. No adverse effects occurred. A 12-week in-hospital training program including high-intensity resistance exercises promotes marked strength improvements in patients during the maintenance phase of the treatment for Acute Lymphoblastic Leukemia without side-effects. Parents' evaluations of their children revealed an improvement in the quality of life.

Influence of Growth Media and Temperature on Bacterial Adhesion to Polystyrene Surfaces

Bacterial adhesion to inert surfaces is a complex process influenced by environmental conditions. In this work, the influence of growth medium and temperature on the adhesion of Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Micrococcus luteus and Listeria monocytogenes to polystyrene surfaces was studied. Most bacteria demonstrated the highest adhesion when cultured in TSYEA, except S. marcescens, which showed to be positively influenced by the pigment production, favored in poor nutrient media (lactose and peptone agar). P. aeruginosa adhesion to polystyrene increased at low temperatures whatever the medium used. The culture medium influenced the surface properties of the bacteria as assessed by the MATS test.

Biomechanical and histologic evaluation of non-washed resorbable blasting media and alumina-blasted/acid-etched surfaces

Objectives: To compare the biomechanical fixation and histomorphometric parameters between two implant surfaces: non-washed resorbable blasting media (NWRBM) and alumina-blasted/acid-etched (AB/AE), in a dog model. Material and methods: The surface topography was assessed by scanning electron microscopy, optical interferometry and chemistry by X-ray photoelectron spectroscopy (XPS). Six beagle dogs of similar to 1.5 years of age were utilized and each animal received one implant of each surface per limb (distal radii sites). After a healing period of 3 weeks, the animals were euthanized and half of the implants were biomechanically tested (removal torque) and the other half was referred to nondecalcified histology processing. Histomorphometric analysis considered bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Following data normality check with the Kolmogorov-Smirnov test, statistical analysis was performed by paired t-tests at 95% level of significance. Results: Surface roughness parameters Sa (average surface roughness) and Sq (mean root square of the surface) were significantly lower for the NWRBM compared with AB/ AE. The XPS spectra revealed the presence of Ca and P in the NWRBM. While no significant differences were observed for both BIC and BAFO parameters (P>0.35 and P>0.11, respectively), a significantly higher level of torque was observed for the NWRBM group (P = 0.01). Bone morphology was similar between groups, which presented newly formed woven bone in proximity with the implant surfaces. Conclusion: A significant increase in early biomechanical fixation was observed for implants presenting the NWRBM surface.

A NEW GENUS AND SPECIES OF PHILOPTERIDAE (PHTHIRAPTERA: ISCHNOCERA) FROM THE TRUMPETERS (AVES: GRUIFORMES: PSOPHIIDAE)

A new chewing louse genus and species belonging to the Philopteridae, namely, Palmaellus inespectatus n. gen., n. sp., is described. The new genus is distinguished from the other ischnoceran genera hitherto described by its peculiar characters of the dorsal anterior head plate with 2 postero-lateral projections, pterothorax and abdomen with scarce chaetotaxy, male genitalia with simple mesomere and paramere lacking inner digitiform projection, and the genital region of female with postero-vulvar plates bearing setae. It is a parasite of the trumpeters, an avian family endemic to South America's Amazon Basin.

Two new genera, ten new species and new records of Amazonian Stygnidae Simon, 1879 (Opiliones: Laniatores)

As a result of recent expeditions to two mountains in the Amazon basin, Tapirapeco and Pico da Neblina, two new genera of Stygnidae, Imeri g. nov. (type species Imeri lomanhungae sp. nov.) and Jime g. nov. (type species Jime chifrudo sp. nov.), and ten new species are described: Auranus hehu sp. nov., Auranus tepui sp. nov., Imeri lomanhungae sp. nov.; Jime chifrudo sp. nov.; Stygnoplus ianomami sp. nov.; Stygnus magalhaesi sp. nov.; Stygnoplus neblina sp. nov.; Stygnoplus tapirapeco sp. nov.; Stygnus nogueirai sp. nov., Stygnus kuryi sp. nov.. Additionally, new distributional records in Amazonas (Brazil) are presented for Stygnidius guerinii Soerensen, 1932, Minax tetraspinosus Pinto-da-Rocha, 1997 and Protimesius longipalpis (Roewer, 1943). Keys for genera of Heterostygninae and Stygninae are provided.

CHEMICAL CONSTITUENTS FROM RED ALGAE Bostrychia radicans (Rhodomelaceae): NEW AMIDES AND PHENOLIC COMPOUNDS

This study describes the isolation and structural determination of two amides, isolated for the first time: N,4-dihydroxy-N-(2'-hydroxyethyl)-benzamide (0.019%) and N, 4-dihydroxy-N-(2'-hydroxyethyl)-benzeneacetamide (0.023%). These amides, produced by the red macroalgae Bostrychia radicans, had their structures assigned by NMR spectral data and MS analyses. In addition, this chemical study led to the isolation of cholesterol, heptadecane, squalene, trans-phytol, neophytadiene, tetradecanoic and hexadecanoic acids, methyl hexadecanoate and methyl 9-octadecenoate, 4-(methoxymethyl)-phenol, 4-hydroxybenzaldehyde, methyl 4-hydroxybenzeneacetate, methyl 2-hydroxy-3-(4-hydroxyphenyl)-propanoate, hydroquinone, methyl 4-hydroxymandelate, methyl 4-hydroxybenzoate, 4-hydroxybenzeneacetic acid and (4-hydroxyphenyl)-oxo-acetaldehyde. This is the first report concerning these compounds in B. radicans, contributing by illustrating the chemical diversity within the Rhodomelaceae family.

A New Genus and Species of a Minute Suckermouth Armored Catfish (Siluriformes: Loricariidae) from the Rio Tocantins Drainage, Central Brazil: The Smallest Known Loricariid Catfish

Nannoplecostomus eleonorae, a new genus and species of a miniature suckermouth armored catfish, is described based on specimens collected from the karst region of Sao Domingos, upper Rio Tocantins basin, Goias State, central Brazil. The new genus and species can be diagnosed among loricariids by presenting a unique reductive pattern of lateral dermal plates, with most of the body covered by only three series of plates (viz., dorsal, mid-ventral, and ventral). Based on the available published phylogenetic studies for the family, we provisionally consider Nannoplecostomus eleonorae as being an incertae sedis taxon within Loricariidae. Achieving a maximum standard length of 22.2 mm SL, Nannoplecostomus eleonorae is the smallest known loricariid catfish, and a list of the remaining smallest loricariids is provided.

New genera and species of Neotropical Rhinotragini (Coleoptera, Cerambycidae, Cerambycinae)

Giesberteclipta and Thomasella, two new genera of Rhinotragini Thomson, 1861 (Coleoptera: Cerambycidae: Cerambycinae), are described and illustrated. Six new species are also described and illustrated: Acyphoderes violaceus from Costa Rica; Ischasioides giesberti from Ecuador, and Oxylymma pallida, Pseudagaone williamsi, Stultutragus tippmanni and S. ventriguttatus from Brazil. Keys are provided for the known species of Pseudagaone Tippmann, 1960, Giesberteclipta, and Oxylymma Pascoe, 1859 and for parts of Ischasioides Tavakilian & Penaherrera-Leiva, 2003 and Stultutragus Clarke, 2010. The following new combinations are proposed: Giesberteclipta costipennis (Giesbert, 1991); G. monteverdensis (Giesbert, 1991); Thomasella igniventris (Giesbert, 1991), and Stultutragus romani (Aurivillius, 1919). The following three new country records are reported: Oxylymma durantoni Penaherrera-Leiva & Tavakilian, 2003 (Brazil), Oxylymma sudrei Penaherrera-Leiva & Tavakilian, 2003 (Brazil), and Ommata (Eclipta) faurei Penaherrera-Leiva & Tavakilian, 2003, all from Brazil.