Human Bone Morphogenetic Protein-2 Use for Maxillary Reconstruction in Cleft Lip and Palate Patients

Background: The conventional methods of maxillary alveolar reconstruction in patient with cleft are the periosteoplasty and autologous bone grafting. As an important alternative of bone substitution, there is the recombinant human bone morphogenetic protein-2 (rhBMP-2). This study compares the rhBMP-2 with periosteoplasty and autologous bone grafting. Methods: Patients with cleft and alveolar defect were divided into 3 groups of 6 patients who underwent to autologous iliac crest bone grafting, resorbable collagen sponge with rhBMP2, and periosteoplasty, respectively. The analysis was performed through computed tomographic scan preoperatively and at months 3, 6, and 12 postoperatively. The variables analyzed were the alveolar defect volume, formed bone volume, bone formation rate, maxillary height repair rate, and the formed bone density mean. Results: The formed bone volume was similar comparing the bone graft and BMP groups at 1-year postoperative analysis (P = 0.58). Both of them had the formed bone volume significantly larger than the periosteoplasty group at 3 and 6 months postoperatively. In this last group, the 1-year follow-up was canceled because the bone formation was insufficient. The bone formation rate, the maxillary height repair rate, and the mean of density of the formed bone were similar in the bone graft and BMP groups at 1-year follow-up with P values of 0.93, 0.90, and 0.81, respectively. Conclusions: The amount of formed bone in the periosteoplasty group was insufficient. There was no difference among the bone graft and rhBMP-2 therapy considering the parameters analyzed.

Análise do conforto térmico na obra de João Filgueiras Lima, Lelé: Hospitais Sarah de Salvador e do Rio de Janeiro

Estratégias passivas de projeto reduzem significativamente o uso de ar condicionado e melhoram o conforto térmico dos usuários. Isto pode ser ilustrado através dos hospitais da Rede Sarah Kubitschek projetados pelo arquiteto João Filgueiras Lima, Lelé, cujas soluções além de propiciarem ambientes mais agradáveis e salubres, evitam o uso de sistemas mecânicos de resfriamento, reduzindo o consumo de energia elétrica. Deste modo, o presente artigo tem como objetivo avaliar o conforto térmico dos hospitais Sarah de Salvador e do Rio de Janeiro, através de medições in loco da temperatura do ar, umidade relativa do ar e velocidade do ar. A análise dos resultados foi baseada em leituras de projeto, na norma ASHRAE Standard 55/2004 e em parâmetros adquiridos na literatura especializada. Os resultados demonstram a preocupação de Lelé na incorporação de aspectos bioclimáticos nos projetos. No Sarah - Salvador, alguns ambientes permaneceram fora da zona de conforto no período do meio dia, devido ao ganho de calor pela cobertura. No entanto, o uso da ventilação natural auxilia no efeito de resfriamento, melhorando o conforto térmico nos espaços internos. Já no Sarah - Rio, todos os ambientes permanecem dentro da zona de conforto proposta pela ASHRAE 55.