Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women

Introduction: Prebiotics positively affect gut microbiota composition, thus improving gut function. These properties may be useful for the treatment of constipation. Objectives: This study assessed the tolerance and effectiveness of a prebiotic inulin/partially hydrolyzed guar gum mixture (I-PHGG) for the treatment of constipation in females, as well as its influence on the composition of intestinal microbiota and production of short chain fatty acids. Methods: Our study enrolled 60 constipated female health worker volunteers. Participants reported less than 3 bowel movements per week. Volunteers were randomized to treatment with prebiotic or placebo. Treatment consisted of 3 weeks supplementation with 15 g/d I-PHGG (fiber group) or maltodextrin (placebo group). Abdominal discomfort, flatulence, stool consistency, and bowel movements were evaluated by a recorded daily questionnaire and a weekly interview. Changes in fecal bacterial population and short chain fatty acids were assessed by real-time PCR and gas chromatography, respectively. Results: There was an increased frequency of weekly bowel movements and patient satisfaction in both the fiber and placebo groups with no significant differences. Total Clostridium sp significantly decreased in the fiber group (p = 0.046) and increased in the placebo group (p = 0.047). There were no changes in fecal short chain fatty acid profile. Conclusions: Consumption of I-PHGG produced clinical results comparable to placebo in constipated females, but had additional protective effects on gut rnicrobiota by decreasing the amount of pathological bacteria of the Clostridium genera.

Revista Crás!: quadrinhos brasileiros e industria editorial

Este artigo tem como objetivo resgatar a trajetória das histórias em quadrinhos brasileiras na década de 1970, considerada de especial relevância para o avanço da arte gráfica sequencial no Brasil. Nesse período, observa-se, de um lado, iniciativas de pequenas editoras localizadas em vários estados brasileiros, e, de outro, empreendimentos feitos por editoras de grande porte na publicação de material nacional. Como estudo de caso, apresenta a revista Crás!, produzida pela Editora Abril, de São Paulo, que reuniu talentos veteranos e jovens da arte gráfica sequencial brasileira. A análise dessa publicação revela as dificuldades do quadrinho brasileiro frente às necessidades e limites das editoras comerciais e do mercado editorial no país.