5 resultados para BJ8-03-129MC

em Biblioteca Digital da Produção Intelectual da Universidade de São Paulo


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Este texto corresponde à primeira parte de meu memorial para a obtenção do título de Livre-Docente na especialidade "Gravura, Matriz e Estampa", junto ao Departamento de Artes Plásticas da Escola de Comunicações e Artes da Universidade de São Paulo. Baseia-se na minha experiência como aluno, professor e artista na Unicamp e na USP. A defesa foi realizada nos dias 23 e 24 de junho de 2008. A banca examinadora foi integrada pelos Professores Doutores Domingos Tadeu Chiarelli (presidente), Marco Garaude Giannotti, Aracy Amaral, Laymert Garcia dos Santos e Celso Favaretto.

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Brazilian National Research Council (CNPq/Brazil)

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Purpose: To report the clinical outcome of the treatment of dry eyes using 0.03% tacrolimus eye drops (olive oil + tacrolimus 0.03%) (Ophthalmos, Sao Paulo, Brazil). Methods: Sixteen eyes of 8 patients with Sjogren syndrome dry eyes (age, 51.13 +/- 9.45 years) were enrolled in this study (prospective noncontrolled interventional case series). Patients were instructed to use topical 0.03% tacrolimus eye drops twice a day (every 12 hours) in the lower conjunctival sac. Schirmer I test, break-up time, corneal fluorescein, and rose bengal staining score were performed in all patients 1 day before, and 14, 28, and 90 days after treatment with 0.03% tacrolimus eye drops. Results: The average fluorescein staining and rose bengal staining scores improved statistically significantly after 14 days of treatment and improved even more after 28 and 90 days. The average Schirmer I test did not improve statistically significantly after 28 days of treatment, although we did observe a significant improvement after 90 days of treatment with 0.03% tacrolimus eye drops. The average break-up time did not improve statistically after 14 days of treatment, although we observed a significant improvement after 28 and 90 days of treatment with 0.03% tacrolimus eye drops. Conclusions: Topical 0.03% tacrolimus eye drops successfully improved tear stability and ocular surface status in patients with dry eyes.

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