31 resultados para Chautauqua Literary and Scientific Circle
Filtro por publicador
- JISC Information Environment Repository (2)
- Repository Napier (1)
- University of Cagliari UniCA Eprints (1)
- Aberdeen University (3)
- Aberystwyth University Repository - Reino Unido (2)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- Adam Mickiewicz University Repository (5)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (4)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (16)
- Archive of European Integration (8)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (6)
- Aston University Research Archive (14)
- B-Digital - Universidade Fernando Pessoa - Portugal (4)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (31)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (11)
- Biblioteca Digital de la Universidad Católica Argentina (6)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (40)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (29)
- Boston University Digital Common (3)
- Brock University, Canada (5)
- Bucknell University Digital Commons - Pensilvania - USA (2)
- Bulgarian Digital Mathematics Library at IMI-BAS (56)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (5)
- CentAUR: Central Archive University of Reading - UK (21)
- Center for Jewish History Digital Collections (2)
- Central European University - Research Support Scheme (2)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (18)
- Cochin University of Science & Technology (CUSAT), India (3)
- Coffee Science - Universidade Federal de Lavras (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (9)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (2)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (41)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Archives@Colby (2)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons @ Winthrop University (1)
- Digital Commons at Florida International University (8)
- Digital Howard @ Howard University | Howard University Research (1)
- Digital Peer Publishing (2)
- DigitalCommons@The Texas Medical Center (2)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (2)
- DRUM (Digital Repository at the University of Maryland) (5)
- Duke University (4)
- Ecology and Society (2)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (2)
- Glasgow Theses Service (4)
- Greenwich Academic Literature Archive - UK (9)
- Harvard University (23)
- Helda - Digital Repository of University of Helsinki (20)
- Indian Institute of Science - Bangalore - Índia (9)
- Institute of Public Health in Ireland, Ireland (1)
- Instituto Politécnico de Castelo Branco - Portugal (1)
- Instituto Politécnico de Leiria (1)
- Instituto Politécnico do Porto, Portugal (8)
- Memoria Académica - FaHCE, UNLP - Argentina (9)
- Memorial University Research Repository (2)
- National Center for Biotechnology Information - NCBI (1)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Portal de Revistas Científicas Complutenses - Espanha (10)
- QSpace: Queen's University - Canada (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (38)
- Queensland University of Technology - ePrints Archive (82)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Aberto da Universidade Aberta de Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (6)
- Repositório Científico do Instituto Politécnico de Santarém - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (9)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (27)
- Royal College of Art Research Repository - Uninet Kingdom (2)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- School of Medicine, Washington University, United States (1)
- SerWisS - Server für Wissenschaftliche Schriften der Fachhochschule Hannover (2)
- Universidad de Alicante (6)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (4)
- Universidade de Lisboa - Repositório Aberto (14)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universidade Metodista de São Paulo (1)
- Universita di Parma (1)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (2)
- Université de Montréal (1)
- Université de Montréal, Canada (11)
- University of Michigan (187)
- University of Queensland eSpace - Australia (4)
- University of Washington (4)
- WestminsterResearch - UK (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Drug dependence is a major health problem in adults and has been recognized as a significant problem in adolescents. We previously demonstrated that repeated treatment with a behaviorally sensitizing dose of ethanol in adult mice induced tolerance or no sensitization in adolescents and that repeated ethanol-treated adolescents expressed lower Fos and Egr-1 expression than adult mice in the prefrontal cortex (PFC). In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice. Adult mice exhibited typical locomotor sensitization after 15 days of daily treatment with 2.0 g/kg ethanol, whereas adolescent mice did not exhibit sensitization. Overall, adolescent mice displayed lower CREB binding activity in the PFC compared with adult mice, whereas opposite effects were observed in the hippocampus. The present results indicate that ethanol exposure induces significant and differential neuroadaptive changes in CREB DNA-binding activity in the PFC and hippocampus in adolescent mice compared with adult mice. These differential molecular changes may contribute to the blunted ethanol-induced behavioral sensitization observed in adolescent mice.