16 resultados para Unicode Common Locale Data Repository
Filtro por publicador
- JISC Information Environment Repository (3)
- Academic Research Repository at Institute of Developing Economies (2)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (6)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (7)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (3)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (12)
- Aston University Research Archive (28)
- Avian Conservation and Ecology - Eletronic Cientific Hournal - Écologie et conservation des oiseaux: (1)
- Biblioteca de Teses e Dissertações da USP (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (16)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (13)
- Biblioteca Virtual del Sistema Sanitario Público de Andalucía (BV-SSPA), Junta de Andalucía. Consejería de Salud y Bienestar Social, Spain (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (48)
- Brock University, Canada (3)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (4)
- CentAUR: Central Archive University of Reading - UK (46)
- CiencIPCA - Instituto Politécnico do Cávado e do Ave, Portugal (1)
- Cochin University of Science & Technology (CUSAT), India (2)
- Coffee Science - Universidade Federal de Lavras (1)
- Collection Of Biostatistics Research Archive (2)
- Consorci de Serveis Universitaris de Catalunya (CSUC), Spain (26)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- CUNY Academic Works (2)
- Dalarna University College Electronic Archive (5)
- Department of Computer Science E-Repository - King's College London, Strand, London (1)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (4)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (7)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- Digital Peer Publishing (2)
- Digital Repository at Iowa State University (2)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (15)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (74)
- DRUM (Digital Repository at the University of Maryland) (32)
- Duke University (4)
- Earth Simulator Research Results Repository (4)
- Galway Mayo Institute of Technology, Ireland (3)
- Glasgow Theses Service (1)
- Harvard University (2)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (3)
- Institute of Public Health in Ireland, Ireland (1)
- Institutional Repository of Leibniz University Hannover (1)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico do Porto, Portugal (7)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (3)
- Martin Luther Universitat Halle Wittenberg, Germany (1)
- Massachusetts Institute of Technology (1)
- Memorial University Research Repository (1)
- Ministerio de Cultura, Spain (1)
- National Center for Biotechnology Information - NCBI (12)
- Nottingham eTheses (2)
- Open Access Repository of Association for Learning Technology (ALT) (4)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (4)
- Publishing Network for Geoscientific & Environmental Data (152)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (5)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (4)
- Repositório da Produção Científica e Intelectual da Unicamp (1)
- Repositorio de la Universidad del Pacífico - PERU (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (18)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (2)
- Repositorio Institucional de la Universidad de Málaga (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (21)
- Repositorio Institucional Universidad Católica de Colombia (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (13)
- Scielo Saúde Pública - SP (10)
- Scottish Institute for Research in Economics (SIRE) (SIRE), United Kingdom (1)
- Universidad de Alicante (8)
- Universidad del Rosario, Colombia (90)
- Universidad Politécnica de Madrid (19)
- Universidade Complutense de Madrid (3)
- Universidade do Minho (7)
- Universidade dos Açores - Portugal (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (4)
- Universitat de Girona, Spain (3)
- Université de Lausanne, Switzerland (62)
- Université de Montréal, Canada (7)
- University of Connecticut - USA (2)
- University of Michigan (3)
- University of Queensland eSpace - Australia (23)
- University of Southampton, United Kingdom (7)
- University of Washington (3)
- WestminsterResearch - UK (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Abstract Background Regardless the regulatory function of microRNAs (miRNA), their differential expression pattern has been used to define miRNA signatures and to disclose disease biomarkers. To address the question of whether patients presenting the different types of diabetes mellitus could be distinguished on the basis of their miRNA and mRNA expression profiling, we obtained peripheral blood mononuclear cell (PBMC) RNAs from 7 type 1 (T1D), 7 type 2 (T2D), and 6 gestational diabetes (GDM) patients, which were hybridized to Agilent miRNA and mRNA microarrays. Data quantification and quality control were obtained using the Feature Extraction software, and data distribution was normalized using quantile function implemented in the Aroma light package. Differentially expressed miRNAs/mRNAs were identified using Rank products, comparing T1DxGDM, T2DxGDM and T1DxT2D. Hierarchical clustering was performed using the average linkage criterion with Pearson uncentered distance as metrics. Results The use of the same microarrays platform permitted the identification of sets of shared or specific miRNAs/mRNA interaction for each type of diabetes. Nine miRNAs (hsa-miR-126, hsa-miR-1307, hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-144, hsa-miR-199a-5p, hsa-miR-27a, hsa-miR-29b, and hsa-miR-342-3p) were shared among T1D, T2D and GDM, and additional specific miRNAs were identified for T1D (20 miRNAs), T2D (14) and GDM (19) patients. ROC curves allowed the identification of specific and relevant (greater AUC values) miRNAs for each type of diabetes, including: i) hsa-miR-1274a, hsa-miR-1274b and hsa-let-7f for T1D; ii) hsa-miR-222, hsa-miR-30e and hsa-miR-140-3p for T2D, and iii) hsa-miR-181a and hsa-miR-1268 for GDM. Many of these miRNAs targeted mRNAs associated with diabetes pathogenesis. Conclusions These results indicate that PBMC can be used as reporter cells to characterize the miRNA expression profiling disclosed by the different diabetes mellitus manifestations. Shared miRNAs may characterize diabetes as a metabolic and inflammatory disorder, whereas specific miRNAs may represent biological markers for each type of diabetes, deserving further attention.