16 resultados para CANCER-RISK ASSESSMENT
Filtro por publicador
- JISC Information Environment Repository (1)
- Abertay Research Collections - Abertay University’s repository (4)
- Aberystwyth University Repository - Reino Unido (2)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (9)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (6)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (12)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (16)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (5)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (62)
- Boston University Digital Common (3)
- Brock University, Canada (4)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- Cambridge University Engineering Department Publications Database (11)
- CentAUR: Central Archive University of Reading - UK (47)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (9)
- Cochin University of Science & Technology (CUSAT), India (1)
- Coffee Science - Universidade Federal de Lavras (1)
- Collection Of Biostatistics Research Archive (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- CUNY Academic Works (1)
- Deakin Research Online - Australia (123)
- Department of Computer Science E-Repository - King's College London, Strand, London (2)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (5)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (2)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (33)
- DigitalCommons@University of Nebraska - Lincoln (2)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (22)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (11)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Glasgow Theses Service (2)
- Greenwich Academic Literature Archive - UK (2)
- Helda - Digital Repository of University of Helsinki (19)
- Hospitais da Universidade de Coimbra (1)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Nacional de Saúde de Portugal (10)
- Instituto Politécnico do Porto, Portugal (7)
- Massachusetts Institute of Technology (1)
- Memoria Académica - FaHCE, UNLP - Argentina (3)
- National Center for Biotechnology Information - NCBI (6)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (4)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (115)
- Queensland University of Technology - ePrints Archive (159)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (2)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (5)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (4)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (5)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (40)
- Repositorio Institucional Universidad de Medellín (2)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (5)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- School of Medicine, Washington University, United States (1)
- Scielo España (1)
- South Carolina State Documents Depository (1)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (7)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universitat de Girona, Spain (1)
- Université de Lausanne, Switzerland (12)
- Université de Montréal (1)
- Université de Montréal, Canada (10)
- Université Laval Mémoires et thèses électroniques (1)
- University of Canberra Research Repository - Australia (4)
- University of Michigan (18)
- University of Queensland eSpace - Australia (55)
- University of Southampton, United Kingdom (3)
- University of Washington (5)
- WestminsterResearch - UK (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Cancers of the upper aerodigestive tract (UADT) are common forms of malignancy associated with tobacco and alcohol exposures, although human papillomavirus and nutritional deficiency are also important risk factors. While somatically acquired DNA methylation changes have been associated with UADT cancers, what triggers these events and precise epigenetic targets are poorly understood. In this study, we applied quantitative profiling of DNA methylation states in a panel of cancer-associated genes to a case-control study of UADT cancers. Our analyses revealed a high frequency of aberrant hypermethylation of several genes, including MYOD1, CHRNA3 and MTHFR in UADT tumors, whereas CDKN2A was moderately hypermethylated. Among differentially methylated genes, we identified a new gene (the nicotinic acetycholine receptor gene) as target of aberrant hypermethylation in UADT cancers, suggesting that epigenetic deregulation of nicotinic acetycholine receptors in non-neuronal tissues may promote the development of UADT cancers. Importantly, we found that sex and age is strongly associated with the methylation states, whereas tobacco smoking and alcohol intake may also influence the methylation levels in specific genes. This study identifies aberrant DNA methylation patterns in UADT cancers and suggests a potential mechanism by which environmental factors may deregulate key cellular genes involved in tumor suppression and contribute to UADT cancers.