Biomimetic Scaffold with Aligned Microporosity Designed for Dentin Regeneration

Tooth loss is a common result of a variety of oral diseases due to physiological causes, trauma, genetic disorders, and aging and can lead to physical and mental suffering that markedly lowers the individual’s quality of life. Tooth is a complex organ that is composed of mineralized tissues and soft connective tissues. Dentin is the most voluminous tissue of the tooth and its formation (dentinogenesis) is a highly regulated process displaying several similarities with osteogenesis. In this study, gelatin, thermally denatured collagen, was used as a promising low-cost material to develop scaffolds for hard tissue engineering. We synthetized dentin-like scaffolds using gelatin biomineralized with magnesium-doped hydroxyapatite and blended it with alginate. With a controlled freeze-drying process and alginate cross-linking, it is possible to obtain scaffolds with microscopic aligned channels suitable for tissue engineering. 3D cell culture with mesenchymal stem cells showed the promising properties of the new scaffolds for tooth regeneration. In detail, the chemical–physical features of the scaffolds, mimicking those of natural tissue, facilitate the cell adhesion, and the porosity is suitable for long-term cell colonization and fine cell–material interactions.

Editorial: European Journal of Case Reports in Internal Medicine

Modern medicine began in the last half of the nineteenth century when doctors started practising the scientific method at the bedside. However, in his presidential address to the Association of American Physicians in 1979 James Wyngaarden postulated that the clinical scientist was an endangered species. Several reasons for this have been suggested, including “the seductive incomes that now derive from procedure-based specialty medicine”. Others have suggested that it is simply because the things left to be discovered at bedside have become exhausted, and that all the big medical advances will now be made by high-powered institutions.

Il «Castellazzo» di Monte Iato in Sicilia occidentale (PA) Quinta e sesta campagna di scavo. Aggiornamenti dal territorio

From May 15th to 30th and 15th to 30th September 2015 took place the fifth and sixth excavation campaign at the Castellazzo of Monte Iato. The presence of 15 participants made it possible to deepen the research significantly and ex-pand the surface area of investigation. It is completely emptied a room already identified in previous campaigns and provided new information about the relationship with the existing cemetery. Part of a burial in a supine position was destroyed by the installation of wall 20. Traces of another turret projecting from the walls have been discovered in the east and another section of the inner walls (15) was fully exposed. A gate, between two towers, is the first entry traced so far, on the north-eastern side of the plateau. The archaeological materials found confirm the characteristics and type of construction. Being a military camp of ephemeral nature, although active at least 30 years, objects such as arrowheads and crossbow quarrels, knives, buckles and harnesses for horses have been found. One of the environments has been interpreted as an area where gaming took place because of the presence of four dice in ivory, glasses and different coins, in addition to the greater extent than the other environments found. Among the findings are reported a glass weight with a cufic inscription dated to the mid-twelfth century and two bronze coins dated in 15th centu-ry.

Prioritization of Multimedication in Multimorbidity: Where Are We Now?

Multimorbidity, the co-occurrence of multiple chronic conditions in an individual, and the frequently associated multimedication is a health issue mostly dealt with in primary care consultations.

Un distillato di bohèmienne tutt'ora famoso: l'assenzio

L'assenzio è un distillato ad alta gradazione alcolica 60-70° all'aroma di anice, generalmente dalla colorazione verde smeraldo o verde chiaro, derivato da erbe quali i fiori e le foglie dell’Artemisia absinthium L. dal quale prende il nome. Le proprietà officinali della pianta sono conosciute ed utilizzate fin dall’antichità dal momento che la pianta e le sue applicazioni terapeutiche sono addirittura citate in un papiro egiziano del 1500 a.C. Tale distillato conobbe una diffusione eccezionale nell’800, e divenne particolarmente noto alla fine del secolo, grazie alla fama che ebbe tra gli artisti e gli scrittori di Parigi. Il successo dell’assenzio in Europa fu clamoroso, ma altrettanto rapido fu poi il suo declino. Infatti, scomparve da tutti i mercati d’Europa e d’oltre oceano in poco più di un decennio. Attualmente l’assenzio, ritornato in voga, trova applicazione durante la celebrazione di numerose ritualità magico-esoteriche dove lo si celebra come capace di ridurre la carica aggressiva, sviluppare la calma e fortificare corpo e mente. Siti internet di matrice magico-occultista riportano il suo consumo durante lo svolgimento di vari rituali. Questo utilizzo “nascosto” ma diffuso ha posto le basi per indagarne il suo reale consumo voluttuario tra i giovani, in considerazione della sua facile reperibilità e dei suoi effetti farmaco-tossicologici.

Magnetic resonance spectroscopy. Data analysis for clinical applications

This text is taken from the postgraduate thesis, which one of the authors (A.B.) developed for the degree of Medical Physicist in the School on Medical Physics of the University of Florence. The text explores the feasibility of quantitative Magnetic Resonance Spectroscopy as a tool for daily clinical routine use. The results and analysis comes from two types of hyper spectral images: the first set are hyper spectral images coming from a standard phantom (reference images); and hyper spectral images obtained from a group of patients who have undergone MRI examinations at the Santa Maria Nuova Hospital. This interdisciplinary work stems from the IFAC-CNR know how in terms of data analysis and nanomedicine, and the clinical expertise of Radiologists and Medical Physicists. The results reported here, which were the subject of the thesis, are original, unpublished, and represent independent work.

Gaslighting: i profili giuridici di una forma di abuso psicologico

Il termine Gaslighting trae origine dal titolo di un’opera teatrale del 1944, “Gaslight”. Narra la storia di un marito che, utilizzando delle strategie, in particolare l’alterazione della luce delle lampade a gas della casa, spinge la moglie a dubitare di se stessa e delle sue capacità critiche fino a condurla sull’orlo della pazzia. Modalità di abuso psicologico che solo di recente ha suscitato l’interesse di studiosi, psicologi, psichiatri, medici e giuristi. Attenzione da attribuire anche ad una maggiore partecipazione ai problemi sociali realizzata dai mass-media che espongono al pubblico quotidiane storie di persecuzioni e maltrattamenti famigliari. Per cui il presente lavoro ha come obiettivo proprio la descrizione del fenomeno del gaslighting, ponendo particolare attenzione agli aspetti prettamente giuridici di questa forma di abuso psicologico.